国际血管壁磁共振斑块成像研究网络的实施:冠军研究的经验

Yannan Yu, Weihai Xu, Arindam Chatterjee, T. Lematty, Meng Yao, Ming-Li Li, T. Brown, Mariangela Spampinato, Renee Martin, M. Chimowitz, C. Derdeyn, T. Turan
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引用次数: 0

摘要

背景与目的:颅内动脉粥样硬化(ICAS)是世界范围内最常见的脑卒中原因之一。高分辨率血管壁磁共振成像(VW-MR)是研究ICAS的常用手段,但为了加快VW-MR ICAS研究领域的进展,需要建立一个多中心的研究网络。我们介绍了我们在中国和北美建立国际VW-MR ICAS合作研究网络的经验,使用一种创新的、疾病特异性的ICAS成像模型来标准化现场的VW-MR序列。方法:以南卡罗来纳医科大学和北京协和医学院为中心协调中心。PUMC根据网络和先前的经验确定了中国境内有潜力合作进行大众汽车- mr ICAS研究的研究中心。所有选定的中心都使用ICAS幻影改进MRI序列,研究主要研究者在扫描过程中几乎实时在场。利用研究团队所有成员的广泛专业知识,有效地校准了MRI序列。所有中心进一步验证了人类受试者的MRI序列。结果:我们确定了11家中国医院作为该网络的潜在合作地点。在选定的11个位点中,有6个位点能够使用ICAS假体和随后的人类受试者完成所需的VW-MR扫描和序列优化。结论:建立跨洲协同VW-MR研究网络,利用疾病特异性幻影,方便高效地进行序列修改,实现图像质量标准化,是未来多中心VW-MR研究的需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Implementation of an International Vessel Wall MR Plaque Imaging Research Network: Experience with the ChAMPION Study
Background and Objective: Intracranial atherosclerosis (ICAS) is one of the most common causes of stroke worldwide. High-resolution Vessel Wall MR imaging (VW-MR) is commonly used to study ICAS, but in order to accelerate advances in the field of VW-MR ICAS research, the establishment of a multicenter research network is needed. We introduce our experience in establishing a collaborative international VW-MR ICAS research network in China and North America using an innovative, disease-specific ICAS imaging phantom for standardization of VW-MR sequences at the sites. Methods: Both the Medical University of South Carolina and Peking Union Medical College functioned as Central Coordinating Centers in the network. PUMC identified research centers within China that had the potential for collaboration on VW-MR ICAS research based on networking and prior experience. All selected centers refined MRI sequences using an ICAS phantom with study principal investigators virtually present in real-time during scanning. MRI sequences were efficiently calibrated utilizing the broad expertise of all members of the research team. All centers further validated MRI sequences with human subjects. Results: We identified 11 Chinese hospitals as the potential collaborating sites for the network. Of the 11 selected sites, six sites were able to complete the required VW-MR scanning and sequence refinement using the ICAS phantom and subsequent human subjects. Conclusion: The study demonstrated the feasibility of establishing a cross-continent collaborative VW-MR research network and the use of a disease-specific phantom to facilitate convenient and efficient sequence modification for image quality standardization, which is needed for future multicenter VW-MR studies.
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