{"title":"以4-溴苯乙酮和苯甲醛为原料在碱性条件下常规和微波辅助合成4 ' -溴查酮","authors":"Iin Narwanti, Hanna Nur Aisyah Afifah","doi":"10.20961/jkpk.v7i3.66765","DOIUrl":null,"url":null,"abstract":"This study focuses on synthesizing 4’-bromochalcone through conventional and irradiation microwave methods to determine each method's time efficiency and yield. 4-Bromoacetophenone was treated with benzaldehyde in the presence of a base. Conventionally, the reaction mixture was stirred at room temperature. While in the microwave irradiation method, the reaction mixture was irradiated at a power of 140 watts. The compound was identified, including the melting point and physicochemical properties. The structure of the compound was confirmed by infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data. The results showed that 4’-bromochalcone had been successfully synthesized using conventional and microwave irradiation methods in a good yield (94.61%±0.6793 and 89.39%±0.6418, consecutively). The structure assignment based on infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data revealed that the synthesized product was 4’-bromochalcone. Synthesis of 4’-bromochalchone using microwave irradiation could be done in a shorter time than the conventional method. ","PeriodicalId":394335,"journal":{"name":"JKPK (Jurnal Kimia dan Pendidikan Kimia)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Conventional and Microwave-Assisted Synthesis of 4’-Bromochalchone Utilizing 4-Bromoacetophenone and Benzaldehyde as Starting Material in Alkaline Condition\",\"authors\":\"Iin Narwanti, Hanna Nur Aisyah Afifah\",\"doi\":\"10.20961/jkpk.v7i3.66765\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study focuses on synthesizing 4’-bromochalcone through conventional and irradiation microwave methods to determine each method's time efficiency and yield. 4-Bromoacetophenone was treated with benzaldehyde in the presence of a base. Conventionally, the reaction mixture was stirred at room temperature. While in the microwave irradiation method, the reaction mixture was irradiated at a power of 140 watts. The compound was identified, including the melting point and physicochemical properties. The structure of the compound was confirmed by infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data. The results showed that 4’-bromochalcone had been successfully synthesized using conventional and microwave irradiation methods in a good yield (94.61%±0.6793 and 89.39%±0.6418, consecutively). The structure assignment based on infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data revealed that the synthesized product was 4’-bromochalcone. Synthesis of 4’-bromochalchone using microwave irradiation could be done in a shorter time than the conventional method. \",\"PeriodicalId\":394335,\"journal\":{\"name\":\"JKPK (Jurnal Kimia dan Pendidikan Kimia)\",\"volume\":\"25 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JKPK (Jurnal Kimia dan Pendidikan Kimia)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.20961/jkpk.v7i3.66765\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JKPK (Jurnal Kimia dan Pendidikan Kimia)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.20961/jkpk.v7i3.66765","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Conventional and Microwave-Assisted Synthesis of 4’-Bromochalchone Utilizing 4-Bromoacetophenone and Benzaldehyde as Starting Material in Alkaline Condition
This study focuses on synthesizing 4’-bromochalcone through conventional and irradiation microwave methods to determine each method's time efficiency and yield. 4-Bromoacetophenone was treated with benzaldehyde in the presence of a base. Conventionally, the reaction mixture was stirred at room temperature. While in the microwave irradiation method, the reaction mixture was irradiated at a power of 140 watts. The compound was identified, including the melting point and physicochemical properties. The structure of the compound was confirmed by infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data. The results showed that 4’-bromochalcone had been successfully synthesized using conventional and microwave irradiation methods in a good yield (94.61%±0.6793 and 89.39%±0.6418, consecutively). The structure assignment based on infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data revealed that the synthesized product was 4’-bromochalcone. Synthesis of 4’-bromochalchone using microwave irradiation could be done in a shorter time than the conventional method.