以4-溴苯乙酮和苯甲醛为原料在碱性条件下常规和微波辅助合成4 ' -溴查酮

Iin Narwanti, Hanna Nur Aisyah Afifah
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引用次数: 0

摘要

本研究主要通过常规微波法和辐照微波法合成4′-溴查尔酮,测定每种方法的时间效率和产率。用苯甲醛在碱的存在下处理4-溴苯乙酮。通常,反应混合物在室温下搅拌。而在微波辐照法中,反应混合物的辐照功率为140瓦。对化合物进行了鉴定,包括熔点和理化性质。化合物的结构通过红外、1H-和13c核磁共振以及质谱数据得到了证实。结果表明:4′-溴查尔酮在常规和微波辐照下均能成功合成,产率分别为94.61%±0.6793和89.39%±0.6418。基于红外、1H-和13c核磁共振以及质谱数据的结构配位表明,合成产物为4′-溴查尔酮。微波辐射合成4′-溴查尔酮的时间比常规方法短。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Conventional and Microwave-Assisted Synthesis of 4’-Bromochalchone Utilizing 4-Bromoacetophenone and Benzaldehyde as Starting Material in Alkaline Condition
This study focuses on synthesizing 4’-bromochalcone through conventional and irradiation microwave methods to determine each method's time efficiency and yield. 4-Bromoacetophenone was treated with benzaldehyde in the presence of a base. Conventionally, the reaction mixture was stirred at room temperature. While in the microwave irradiation method, the reaction mixture was irradiated at a power of 140 watts. The compound was identified, including the melting point and physicochemical properties. The structure of the compound was confirmed by infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data. The results showed that 4’-bromochalcone had been successfully synthesized using conventional and microwave irradiation methods in a good yield (94.61%±0.6793 and 89.39%±0.6418, consecutively). The structure assignment based on infrared, 1H- and 13C-nuclear magnetic resonance, and mass spectroscopy spectral data revealed that the synthesized product was 4’-bromochalcone. Synthesis of 4’-bromochalchone using microwave irradiation could be done in a shorter time than the conventional method. 
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