默本概念:对以氧为中心的细胞呼吸的简单解释

K. Manoj
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引用次数: 17

摘要

通过伴随的交流(我工作的第一部分),我最终揭穿了线粒体氧化磷酸化的流行解释,并建立了一个新的基本原理来解释反应范式的必要性。同样,murburn概念在此被提出作为一个可行的解释(在我的工作的第二部分)。线粒体内膜(包含各种金属和黄素酶复合物)作为限制和稳定自由基反应的手段,在质子缺乏的微观世界中,自由基反应有效地偶联并导致ATP合成。所提出的方案是无序的,受到奥卡姆剃刀理论和进化观点的青睐。默本概念是生物化学的一个范式转变,因为它主张扩散活性(氧)物种是线粒体内常规细胞代谢过程的支柱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Murburn concept: A facile explanation for oxygen-centered cellular respiration
Via a concomitant communication (the first part of my work), I have conclusively debunked the prevailing explanations for mitochondrial oxidative phosphorylation and established the need for a novel rationale to account for the reaction paradigm. Towards the same, murburn concept is hereby floated as a viable explanation (in the second part of my work). It is proposed that the inner mitochondrial membrane (harboring the various metal and flavin enzyme complexes) serves as means to confine and stabilize radical reactions, which effectively couple and bring about ATP synthesis in the proton-deficient microcosm. The proposed scheme is un-ordered and favored by Ockham's razor and evolutionary perspectives. Murburn concept is a paradigm-shift in biochemistry because it advocates that diffusible reactive (oxygen) species are mainstay of routine cellular metabolic process within the mitochondria.
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