Preliminary Investigation of the Impact of Mechanical Stresses on Bioimpedance Spectroscopy-based Insuline Bioavailability Assessment

In the framework of bioimpedance spectroscopy-based insulin bioavailability assessment, a preliminary experimental campaign aimed to investigate the relationship between applied pressure and impedance variation was conducted. The experimental tests were carried out on a volunteer's abdomen in a controlled environment. They exploited four pre-gelled electrodes and a non- invasive instrument built with off-the-shelf components, namely DUSM, previously successfully used by the authors in different biomedical applications. Experimental results are compatible with the scientific literature, and show a progressive increase of the impedance magnitude according to an increasing external force which is comparable to the typical mechanical action of an insulin injection.