GO可视化浏览器

Sara Tily, M. C. Murphy, Omkar Dangat, Christopher D. Smith
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引用次数: 0

摘要

生物学家通常使用本体术语注释基因组和蛋白质特性。虽然生物学家对潜在的生物学有深刻的理解,但他们很少对用于表示领域本体的语义网络有很好的理解。本文介绍了GO可视化浏览器的设计和实现:一个提供基因本体术语和关系可视化以及相关基因组数据检索的新工具。浏览包括选择一个术语和本体关系的类型,然后显示包含所有相关术语的交互式地图。然后可以使用该地图在基因组数据库中搜索所有特征、相关序列和用所选本体术语注释的元数据。我们的代码功能齐全,并作为开源软件发布。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
GO Visual Browser
Biologists commonly annotate genome and protein properties using ontology terms. While biologists have a deep understanding of the underlying biology, they rarely have a good understanding of the semantic networks used to represent domain ontologies. This paper presents the design and implementation of the GO Visual Browser: a new tool to provide visualization of Gene Ontology terms and relationships, as well as retrieval of associated genomic data. Browsing involves selecting a term and type of ontology relationship, and then displaying an interactive map with all of the related terms. This map can then be used to search a genome database for all features, related sequences, and metadata annotated with the selected ontology terms. Our code is fully functional and is being distributed as open source software.
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