通过流体流动分析研究皮质内表面和骨膜表面皮质骨适应的差异

Sanjay Singh, Satwinder Singh, Jitendra Prasad
{"title":"通过流体流动分析研究皮质内表面和骨膜表面皮质骨适应的差异","authors":"Sanjay Singh, Satwinder Singh, Jitendra Prasad","doi":"10.1115/imece2021-71220","DOIUrl":null,"url":null,"abstract":"\n Load-induced fluid flow in lacunar-canalicular porosity in bone has been suggested to play an essential role in bone adaptation. The applied load causes the fluid inside the lacunar-canalicular system to flow. The osteocytes are believed to sense the shear stress exerted due to the fluid flow and drive new bone formation. The energy dissipated in moving fluid may be considered as a stimulus for bone adaptation. The endocortical bone surfaces are also believed to adapt differently compared to the periosteal surfaces. We investigate such differences and present a finite element poroelasticity-based mathematical model on estimating bone formation rate at mid-diaphysis of a C57BL6 mouse tibia subjected to cantilever loading. A weighted average of dissipation energy in the zone of influence has been considered in accordance with the literature. The model predicts bone formation rate (BFR) at the periosteal surface as well as on the endocortical surface. As desired, the model can differentiate between a continuous cyclic loading and a rest-inserted cyclic loading. The model establishes that the difference in bone formation at the two surfaces, viz. endocortical and periosteal, may be due to the difference in dissipation energy density only, caused by different boundary conditions at the two surfaces.","PeriodicalId":314012,"journal":{"name":"Volume 5: Biomedical and Biotechnology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the Difference in Cortical Bone Adaptation at Endocortical and Periosteal Surfaces by Fluid Flow Analysis\",\"authors\":\"Sanjay Singh, Satwinder Singh, Jitendra Prasad\",\"doi\":\"10.1115/imece2021-71220\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n Load-induced fluid flow in lacunar-canalicular porosity in bone has been suggested to play an essential role in bone adaptation. The applied load causes the fluid inside the lacunar-canalicular system to flow. The osteocytes are believed to sense the shear stress exerted due to the fluid flow and drive new bone formation. The energy dissipated in moving fluid may be considered as a stimulus for bone adaptation. The endocortical bone surfaces are also believed to adapt differently compared to the periosteal surfaces. We investigate such differences and present a finite element poroelasticity-based mathematical model on estimating bone formation rate at mid-diaphysis of a C57BL6 mouse tibia subjected to cantilever loading. A weighted average of dissipation energy in the zone of influence has been considered in accordance with the literature. The model predicts bone formation rate (BFR) at the periosteal surface as well as on the endocortical surface. As desired, the model can differentiate between a continuous cyclic loading and a rest-inserted cyclic loading. The model establishes that the difference in bone formation at the two surfaces, viz. endocortical and periosteal, may be due to the difference in dissipation energy density only, caused by different boundary conditions at the two surfaces.\",\"PeriodicalId\":314012,\"journal\":{\"name\":\"Volume 5: Biomedical and Biotechnology\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Volume 5: Biomedical and Biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1115/imece2021-71220\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Volume 5: Biomedical and Biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1115/imece2021-71220","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

载荷诱导的流体在骨腔管孔隙中的流动被认为在骨适应中起重要作用。施加的载荷使腔管系统内的流体流动。骨细胞被认为能够感知由于流体流动而施加的剪切应力并驱动新骨的形成。在运动流体中耗散的能量可被认为是骨适应的一种刺激。与骨膜表面相比,皮质内骨表面也被认为具有不同的适应性。我们研究了这些差异,并提出了一个基于有限元孔隙弹性的数学模型,用于估计C57BL6小鼠胫骨在悬臂载荷下的中骨干骨形成率。根据文献考虑了影响区耗散能的加权平均值。该模型预测骨膜表面和皮质内表面的骨形成率(BFR)。根据需要,该模型可以区分连续循环加载和插入休息循环加载。该模型表明,在皮质内和骨膜两个表面上骨形成的差异可能仅仅是由于两个表面上不同的边界条件引起的耗散能密度的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigating the Difference in Cortical Bone Adaptation at Endocortical and Periosteal Surfaces by Fluid Flow Analysis
Load-induced fluid flow in lacunar-canalicular porosity in bone has been suggested to play an essential role in bone adaptation. The applied load causes the fluid inside the lacunar-canalicular system to flow. The osteocytes are believed to sense the shear stress exerted due to the fluid flow and drive new bone formation. The energy dissipated in moving fluid may be considered as a stimulus for bone adaptation. The endocortical bone surfaces are also believed to adapt differently compared to the periosteal surfaces. We investigate such differences and present a finite element poroelasticity-based mathematical model on estimating bone formation rate at mid-diaphysis of a C57BL6 mouse tibia subjected to cantilever loading. A weighted average of dissipation energy in the zone of influence has been considered in accordance with the literature. The model predicts bone formation rate (BFR) at the periosteal surface as well as on the endocortical surface. As desired, the model can differentiate between a continuous cyclic loading and a rest-inserted cyclic loading. The model establishes that the difference in bone formation at the two surfaces, viz. endocortical and periosteal, may be due to the difference in dissipation energy density only, caused by different boundary conditions at the two surfaces.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信