肾移植患者病原真菌的常规和分子鉴定

Faheema Jabbar, A. Al-Attraqchi, Dina Nabeel Alkhayyat
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引用次数: 0

摘要

肾移植患者免疫功能低下引起的机会性真菌感染与高发病率和死亡率相关,尽管发病率很低。侵袭性真菌感染(IFIs)的识别延迟将导致治疗延迟,并导致这些人群的高死亡率。本研究旨在通过传统方法和分子方法评估肾移植受者侵袭性真菌感染的频率。这项研究包括从巴格达医疗城肾脏疾病和移植中心收集的100名肾移植受者(75名男性,25名女性)。在2018年6月至2019年4月期间采集了血液样本。100例肾移植患者中有21例感染病原真菌,其中女性4例,男性17例。根据PCR和培养结果观察到血尿素值异常的患者真菌血症的发生率高。真菌分离株中以酿酒酵母(Saccharomyces cerevisiae)最多,占21株中的19株,其余2株为Zygosaccharomyces rouxii和Aspergillus flavus。本研究结果显示,PCR与培养方法之间存在显著相关性(P<0.0009)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of Pathogenic Fungi in Renal Transplant Patients by Conventional and Molecular Methods
Opportunistic fungal infections due to the immune- compromised status of renal transplant patients are related to high rates of morbidity and mortality regardless of their minor incidence. Delayed in identification of invasive fungal infections (IFIs), will lead to delayed treatment and results in high mortality in those populations. The study aimed to assess the frequency of invasive fungal infection in kidney transplant recipients by conventional and molecular methods. This study included 100 kidney transplant recipients (KTR) (75 males, and 25 females), collected from the Centre of Kidney Diseases and Transplantation in the Medical City of Baghdad. Blood samples were collected during the period from June 2018 to April 2019. Twenty one out of 100 renal-transplanted patients were infected with pathogenic fungi, four of the patients were females and 17 were males. There is an observation of a high incidence of fungemia in patients with the abnormal value of blood urea according to PCR and culture results. Referring to fungal isolates the most prevalent was Saccharomyces cerevisiae, which account for 19 isolates out of 21 the other two isolates were Zygosaccharomyces rouxii and Aspergillus flavus. The results of the current study show significant correlation between PCR and culture methods at (P<0.0009).
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