设计一种便携式葡萄糖测量生物传感系统

Jui-Lin Lai, Han-ning Wu, Hung-Hsi Chang, Rong-Jian Chen
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引用次数: 13

摘要

本文提出了一种由带有葡萄糖测试条电极的恒电位器和自动读出葡萄糖浓度相关电子信号的测试系统组成的电化学传感器。改进、分析并实现了一种基于运算的恒电位器结构。工作操作非常复杂,具有一定的加工性质。通过在三电极上施加0.4 ~ 1.4 v的循环伏安法,这些性能将直接影响氧化还原反应。成功地设计了恒电位器的读出电路,并用HSPICE软件进行了仿真。读出的数据由NI DAQ卡和协调的实验室视图编程的测试时间表自动访问,以控制相关仪器与gip,以获得不同葡萄糖浓度的实验结果。实现了葡萄糖检测系统与改进的基于op的恒电位器和自动测试系统相结合。本文的目的是研究改进的基于op的三电极恒电位器在电化学葡萄糖生物传感器系统中的应用,以获得更准确的测量结果。实验结果表明,恒电位器产生的输出电压范围较线性,对应于所测葡萄糖浓度在4.4V ~ 0.6V之间,范围分别为50 ~ 600mg/dl。恒电位器的结构可以集成到VLSI设计中。便携式生物检测系统在卫生保健和生物医学领域具有很大的应用潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Design a Portable Bio-Sensing System for Glucose Measurement
In the paper, the electrochemical sensor consists of the potantiostat with glucose test strip electrode and the automatic test system to readout the electronic signal related to the concentration of Glucose is proposed. The structure of an Op-based potentiostat is improved, analyzed, and implemented. The working operations are very complicated, and having some processing property. These performances will directly influence to oxidation-reduction reaction through the cyclic voltammetry bounded from 0.4V to-1.4V is applied on the three-electrode. The readout circuit of potentiostat is successfully designed and simulated by HSPICE. The readout data is automatically accessed by the NI DAQ card and the coordinated Lab view programming the test schedule to control the related instrumentation with GPIP to obtain the experiment result for various glucose concentrations. The glucose detection system associated with the improved Op-based potentiostat and an automatic test system is realized. The objective of this paper was to investigate the improved OP-based three-electrode potentiostat used in electrochemical glucose biosensor system to obtain more accuracy the measurement results. The experiment result show that the potentiostat is produced more linearity output range of voltage from 4.4V to 0.6V corresponding to the measured concentration of glucose due to 50-600mg/dl range, respectively. The architecture of the potentiostat can be intergraded for VLSI design. There have a great potential in the portable bio-detection system for the health-care and bio-medicine applications.
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