基于知识图谱的新型冠状病毒药物与症状研究平台

Zhenhe Pan, Shuang Jiang, Juntao Su, Muzhe Guo, Yuanlin Zhang
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引用次数: 0

摘要

自2019年12月发现第一例COVID-19病例以来,已经测试了大量不同的药物来治疗COVID-19,这使得跟踪COVID-19研究领域的快速增长成为一项艰巨的任务。利用现有的科学文献检索系统来深入了解COVID-19相关的临床实验和结果变得越来越复杂。在本文中,我们建立了一个基于命名实体识别的框架,从大量的临床试验结果文章中准确地提取信息,并高效地生成知识图谱。在治疗COVID-19的测试药物中,我们还开发了一个问答系统,使用维基百科文章回答有关COVID-19相关症状的医学问题。我们结合了最先进的问答模型-双向编码器表示从变压器(BERT),知识图谱来回答病人的问题,关于治疗方案的症状。生成的知识图谱具有用户友好性和直观方便的工具,可以查找具有副作用、目标人群等属性的某些药物的支持和/或矛盾参考文献。经过训练的问答平台提供了一种简单、容错的方式,可以根据用户输入的症状查询治疗建议。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Knowledge graph based platform of COVID-19 drugs and symptoms
Since the first cased of COVID-19 was identified in December 2019, a plethora of different drugs have been tested for COVID-19 treatment, making it a daunting task to keep track of the rapid growth of COVID-19 research landscape. Using the existing scientific literature search systems to develop a deeper understanding of COVID-19 related clinical experiments and results turns to be increasingly complicated. In this paper, we build a named entity recognition-based framework to extract information accurately and generate knowledge graph efficiently from a myriad of clinical test results articles. Of the tested drugs to treat COVID-19, we also develop a question answering system answers to medical questions regarding COVID-19 related symptoms using Wikipedia articles. We combine the state-of-the-art question answering model - Bidirectional Encoder Representations from Transformers (BERT), with Knowledge Graph to answer patients' questions about treatment options for their symptoms. This generated knowledge graph is user-friendly with intuitive and convenient tools to find the supporting and/or contradictory references of certain drugs with properties such as side effects, target population, etc. The trained question answering platform provides a straightforward and error-tolerant way to query for treatment suggestions given uses' input symptoms.
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