线性和环状寡肽的非核糖体生物合成

Biopolymers Online Pub Date : 2002-12-09 DOI:10.1002/3527600035.BPOL7003

H. Döhren

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引用次数: 0

摘要

介绍历史介绍非核糖体肽合成酶系统中的蛋白质和蛋白质结构域腺苷酸结构域中间体转运的载体结构域缩合结构域和相关的外映结构域硫酯酶结构域n-甲基转移酶结构域氧化和还原结构域多步骤流水线副反应裁剪反应生物合成基因簇的分离和克隆NRPS簇的发生和检测原核生物中NRPS簇的结构真核NRPS系统的操纵NRPS系统的代谢工程与异源表达编程的遗传改变展望与展望关键词:肽合成酶;non-ribosomal系统;thiotemplate机制;多酶的系统;肽;环肽;肽生物合成

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Non-ribosomal Biosynthesis of Linear and Cyclic Oligopeptides

Introduction Historical Introduction Proteins and Protein Domains in Non-ribosomal Peptide Synthetase Systems Adenylate Domains Carrier Domains for the Transport of Intermediates Condensation Domains and Related Epimerization Domains Thioesterase Domains N-methyltransferase Domains Oxidation and Reduction Domains The Reaction Cycle The Multi-step Assembly Line Side Reactions Tailoring Reactions Isolation and Cloning of Biosynthetic Gene Clusters Occurrence and Detection of NRPS Clusters Structure of NRPS Clusters in Prokaryotes Eukaryotic NRPS Systems Manipulation of NRPS Systems Metabolic Engineering and Heterologous Expression Genetic Alterations of Programming Outlook and Perspectives Keywords: peptide synthetase; non-ribosomal system; thiotemplate mechanism; multienzyme systems; peptides; cyclopeptides; peptide biosynthesis

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Biopolymers Online

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