Hypothyroidism in miscarriage abortion during second trimester regarding on the ABO- Rh blood system

The spontaneous loss of conception before 20-21weeks of gestation called miscarriage, and thyroid dysfunction acts as risk factor for recurrent abortion for negative R uses of goiter pregnancy. The Study aimed to investigate the hypothyroidism goiter state in miscarriage abortion during second trimester reliance upon blood groups and R uses system. Material& Methods:135 subjects was carried out in prospective study at Kirkuk teaching hospital, since from April to first of July 2021 .The study included 45 cases of miscarriage abortions, while 45 was healthy control pregnancy and study constituted 45 women with goiter hypothyroidism of same fertility age ranged at 27- 40 years determined hormones level (T4 (thyroxin), T3 (triiodothyronine), TSH (thyroid stimulating hormone), LH (luteinization hormone), Prolactin (PRL) by ELISA method, and blood groups antigen due to reaction with antibody serum pregnancy and abortion by using slide test method. Questionnaire was complete taken for all women, such as metabolic, chronic diseases and endocrine disorder. Results: The mean T4 level in cases of recurrent abortion was (119.21±1.98 mmol/l), while in control group was (4.78±0.76ng/dl) during second trimester in negative R uses groups, the mean level of LH in negative R uses group in recurrent abortion cases was (9.91±1.23 mu/l),, while in control group was (6.41±1.18 mmol/l) during second trimester for negative Ruses group, and the level of T3 was (17.21±1.42 mmol/l) in miscarriage abortion while in control group was (1.56±0.5 ng/dl) during second trimester at p<0.05. Identifications of blood groups and Ruses factor in healthy pregnant was (30 women Rh+) and (15 women Rh_) when (17 blood group A, 13 blood group B), while in miscarriage abortion was (18 women Rh+) and (27womenRh_), when (11 blood group A, 20 blood group B). Conclusion: The hypothyroidism goiter pregnancy repressed LH and prolactin highly level during miscarriage abortion lead to outcome of pregnancy under lowering level of T4, TSH suppression in negative Ruses with blood group B at age ranged about 27- 40years thru second trimester after 21 weeks ago of the gestation.