调节性机械性黄疸肝脏形态(实验研究)

F. Makhmadov, A. S. Ashurov, E. H. Tagoikulov
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摘要

的目标。目的:观察控制性梗阻性黄疸实验动物肝脏形态学变化。本研究以24只雄性新吉拉兔和18只雌雄大鼠为对象,在相同的饲养和饮食条件下进行了实验研究。为了建立不同程度的梗阻性黄疸模型,将动物分为三组。第一组动物(n=8)在胆囊切除术和胆总管引流后,在48小时内肝胆总管完全阻断。II组(n=8)包括肝胆总管阻滞持续48-60小时的动物,III组(n=8)包括肝胆总管阻滞超过60小时的动物。实验动物肝活检标本的组织学检查显示,与健康动物的肝脏相比,梗阻性黄疸建模的持续时间在实质中发生了明显的形态学变化。在I组动物的病理组织学研究中,肝脏微制剂显示整个切片区域颜色不均匀,中心静脉扩张,形状改变,少量红细胞痕迹。II组和III组的活检标本分析显示肝细胞出现不可逆的营养不良和坏死过程。因此,以可控梗阻性黄疸模型为前提的实验研究表明,在不同的时间间隔内,肝胆总管的完全阻塞与肝细胞损伤相对应,并以不断升级的胆汁淤积过程为基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liver morphology in regulated mechanical jaundice (experimental study)
Aim. To examine the morphology of the liver in controlled obstructive jaundice in experimental animalsMaterials and Methods. This research was conducted through an experimental study involving 24 male Shingilla rabbits and 18 white rats of both sexes, all of which were maintained under identical conditions of care and diet. To establish a model of varying degrees of obstructive jaundice, the animals were divided into three groups. Group I comprised animals (n=8) which, following cholecystectomy and drainage of the choledochus, experienced a complete block of hepaticocholedochus within 48 hours. Group II (n=8) included animals wherein the block of hepaticocholedochus persisted for 48-60 hours, and Group III (n=8) involved animals experiencing more than 60 hours of hepaticocholedochus blockage.Results. Histological examination of liver biopsy specimens from the experimental animals revealed distinctive morphological changes in the parenchyma based on the duration of obstructive jaundice modeling, as compared to the liver of a healthy animal. In the pathohistological study of the Group I animals, liver micro-preparations displayed uneven color throughout the entire area of the sections, central vein expansion with altered shape, and traces of a small number of erythrocytes. Analysis of biopsy specimens from Groups II and III revealed irreversible dystrophic and necrotic processes in hepatocytes.Conclusion. Thus, experimental studies, premised on the modeling of controlled obstructive jaundice, revealed that complete blockage of the hepaticocholedochus, over varying time intervals, corresponded with hepatocyte damage, underpinned by escalating cholestatic processes.
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