{"title":"环状rna作为系统性红斑狼疮新生物标志物的检测技术","authors":"G. Mihaylova, M. Kosturkova, M. Radanova","doi":"10.14748/SSP.V7I2.7375","DOIUrl":null,"url":null,"abstract":"Systemic lupus erythematosus (SLE) is severe, chronic autoimmune disease affecting mainly young active individuals, leading to disability and premature death. Recent studies have reported long non-coding RNAs (lncRNAs) to participate in the pathogenesis of the disease. Among lncRNAs, the circular RNAs (circRNAs) gain growing scientific attention due to their stability in body fluids. This makes them suitable for new non-biomarkers for evaluation of SLE activity and promising therapeutic targets. Methods for detecting of circRNAs are evolving rapidly. The aim of this review is to present these techniques and their advantages and disadvantages.","PeriodicalId":186809,"journal":{"name":"Scripta Scientifica Pharmaceutica","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Detection techniques of circular RNAs as new biomarkers in systemic lupus erythematosus\",\"authors\":\"G. Mihaylova, M. Kosturkova, M. Radanova\",\"doi\":\"10.14748/SSP.V7I2.7375\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Systemic lupus erythematosus (SLE) is severe, chronic autoimmune disease affecting mainly young active individuals, leading to disability and premature death. Recent studies have reported long non-coding RNAs (lncRNAs) to participate in the pathogenesis of the disease. Among lncRNAs, the circular RNAs (circRNAs) gain growing scientific attention due to their stability in body fluids. This makes them suitable for new non-biomarkers for evaluation of SLE activity and promising therapeutic targets. Methods for detecting of circRNAs are evolving rapidly. The aim of this review is to present these techniques and their advantages and disadvantages.\",\"PeriodicalId\":186809,\"journal\":{\"name\":\"Scripta Scientifica Pharmaceutica\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-02-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scripta Scientifica Pharmaceutica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14748/SSP.V7I2.7375\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scripta Scientifica Pharmaceutica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14748/SSP.V7I2.7375","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Detection techniques of circular RNAs as new biomarkers in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is severe, chronic autoimmune disease affecting mainly young active individuals, leading to disability and premature death. Recent studies have reported long non-coding RNAs (lncRNAs) to participate in the pathogenesis of the disease. Among lncRNAs, the circular RNAs (circRNAs) gain growing scientific attention due to their stability in body fluids. This makes them suitable for new non-biomarkers for evaluation of SLE activity and promising therapeutic targets. Methods for detecting of circRNAs are evolving rapidly. The aim of this review is to present these techniques and their advantages and disadvantages.
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