One Case of Refractory Condyloma Acuminatum in Children with Persistent HPV51 Infection Treated By Chinese Medicine Paiteling

A 3-year-old female presented with neoplasms on the perianal for1 month. Physical examination:Multiple needle tips appearing around the anus to millet size. A few vegetations are seen at the vaginal opening. Human papilloma virus (HPV) typing: HPV51 positive. HIV, TPPA, and RPR tests were negative. Histopathology of skin lesions: hyperkeratosis of the epidermis with incomplete keratosis, hyperplasia and hypertrophy of the spinous layer, papilloma-like hyperplasia, vacuolated cells seen above the spinal layer; Diagnosis: Condyloma acuminatum. Treatment: 4 times of photodynamic therapy was ineffective, HPV-51 continued to be positive, and then switched to the Chinese medicine Paiteling three-stage therapy. No new warts were found after follow-up for 1 year, and the HPV-51 turned negative.