氯- e6光动力治疗基底细胞癌

V. Kapinus, M. Kaplan, E. V. Yaroslavtseva-Isayeva, I. S. Spichenkova, S. A. Ivanov
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引用次数: 1

摘要

研究目的:氯e6光动力疗法(PDT)联合光敏剂(PS) photodiazine、photolone和photoran治疗基底细胞皮肤癌的疗效评价材料和方法。本文对532例28 ~ 93岁的基底细胞皮肤癌(BCC)患者使用氯代E6-PDT的疗效进行了研究。PhS photodiazine用于72例(13.5%)患者,剂量为0.5-1.0 mg/kg; PhS Photolon用于281例(52.8%)患者,剂量为1.1-1.6 mg/kg; PhS Photoran用于179例(33.6%)患者,剂量为1.1-1.6 mg/kg。采用激光装置“Latus-2”(662 nm),以200-500 mW/cm2的功率密度对肿瘤病灶进行局部照射,光能剂量为100-300-600 J/cm2。在6个月至5年的随访期间,研究组的复发率为16.2%。当分析结果时,发现在首次接受PDT的患者中,使用所有ph时,复发的百分比最小,达到2.2%(183例患者中有4例),并且在超过2.0 cm和高达4.0 cm的过程中,发现9.5%(105例患者中有10例)复发。在皮肤恶性肿瘤复发的治疗结果与PDT使用衍生品的氯E6,根据流程的流行,一个类似的趋势观察:与肿瘤病灶的大小2.0厘米,反复复发的百分比越来越达17.1% 105年(18例)治疗肿瘤超过2.0厘米和4.0厘米(28.8%的患者复发- 21 73).Conclusions。氯- E6-PDT可以有效治疗独立变异的原发性和复发性基底细胞癌,治疗结果取决于许多因素,包括疾病的流行程度和以前是否接受过治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chlorin E6-photodynamic therapy basal cell carcinoma
Purpose of the study. Evaluation of the therapeutic efficacy of chlorin E6-photodynamic therapy (PDT) with photosensitizers (PS) photoditazine, photolone and photoran in patients suffering basal cell skin carcinoma.Materials and methods. The efficacy of chlorin E6-PDT was studied in 532 patients with basal cell skin cancer (BCC) aged 28 to 93 years. PhS Photoditazine was used in 72 (13,5 %) patients at a dose of 0.5-1.0 mg/kg, PhS Photolon - in 281 (52,8 %) patients at a dose of 1.1-1.6 mg/kg and PhS Photoran - in 179 (33,6 %) people at a dose of 1.1-1.6 mg/kg.Sessions of local irradiation of tumor foci were performed on a laser device "Latus-2" (662 nm) with a power density of 200-500 mW/cm2, light energy was applied to the tumors at a dose of 100-300-600 J/cm2.Results. During the follow-up period from 6 months to 5 years, 16.2 % of cases of relapse were diagnosed in the study group. When analyzing the results, it was found that the percentage of relapses was minimal when using all PhS in patients who underwent PDT for the first time established BCC of the initial stages (neoplasms up to 2.0 cm) and amounted to 2.2 % (4 patients out of 183), and with a prevalence of the process of more than 2.0 cm and up to 4.0 cm, 9.5 % (10 patients out of 105) of relapses were found. In the results of treatment of recurrent skin malignancies with PDT using derivatives of chloride E6, depending on the prevalence of the process, a similar trend was observed: with the size of tumor foci up to 2.0 cm, the percentage of repeated relapses was less and amounted to 17.1 % (18 patients out of 105) than in the treatment of neoplasms more than 2.0 cm and up to 4.0 cm (28.8 % of relapses - 21 patients out of 73).Conclusions. Chlorin E6-PDT makes it possible to effectively treat primary and recurrent BCC in an independent variant, and the results of treatment depend on a number of factors, including the prevalence of the disease and the presence or absence of previous treatment.
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