Mauricio Vargas Malagón, Villar raga, Mantilla P, Montenegro L, Ortega O
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Bioequivalence study of two formulations containing isotretinoin in fed condition in Colombian healthy volunteers
Retinoids are intracrine and paracrine mediators that intervene in apoptosis, proliferation and reproduction of cell differentiation, by binding to nuclear retinoic receptors. Isotretinoin in oral presentation has as its main effect sebaceous secretion reduction, which is reached in 80% by the fourth week of treatment.1 Isotretinoin ́s gastrointestinal absorption exhibits a high variability, which is greatly influenced by the presence or absence of food.2
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