用于闭环治疗优化的心血管模型

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991 Pub Date : 1991-10-31 DOI:10.1109/IEMBS.1991.684950

E. A. Woodruff, J.F. Martin, E. C. Borden

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引用次数: 0

摘要

本文的目的是讨论一个非线性，综合心血管模型的发展和评价闭环治疗。该模型包括三种心血管药物的药代动力学和药效学效应。本文将以硝普钠为例，重点介绍硝普钠作为动脉阻力和静脉张力的函数对平均动脉压的药代动力学和药效学影响。此外，硝普钠的药理学模型将通过文献中的实验数据进行验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Cardiovascular Model For The Optimization Of Closed Loop Therapy

The objective of this paper is to discuss a nonlinear, comprehensive cardiovascular model for the development and evaluation of closed loop therapy. This model includes the pharmacokinetic and pharmacodynamic effects of three cardiovascular agents. As an example, this paper will focus on the pharmacokinetics and pharmacodynamics effects of sodium nitroprusside on mean arterial pressure as a function of arterial resistance and venous tone. Furthermore, this pharmacological model of sodium nitroprusside will be verified with experimental data presented in the literature.

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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991

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