基于监督机器学习方法的帕金森病步态分类

Choon-Hian Goh, Chee Hong Koh, Y. Z. Chong, Wei Yin Lim
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引用次数: 0

摘要

步态分析对于步态障碍的诊断、评估、监测和预测具有重要意义。然而,由于来源覆盖面有限,客观分析方法在医院环境中用于治疗目的的可行性较低。因此,本研究旨在开发一种能够使用相对简化的时空步态数据对被试进行有效分类的分类算法。本研究使用了从PhysioNet获取的几个数据集,其中包含三个类别的受试者步态数据。训练数据集包含三个目标类别(年轻健康成年人,老年健康成年人和帕金森病患者)的48,318个实例。提出两种分类算法:支持向量机(SVM)分类算法和人工神经网络(ANN)分类算法。对原始数据集进行预处理,包括数据清洗、数据归一化和新特征生成。接下来,对操纵超参数进行微调,并应用10倍交叉验证。优化后的SVM模型配置,计算时间为43 min,准确率为93.01%,F1分数为0.92。相反,最优配置ANN分类器的准确率为90.56%,F1分数为0.89,计算时间为112分钟。结论:综上所述,比较两种分类算法,SVM分类器总体上比ANN分类器更有效。此外,在与其他最先进的步态分类算法进行比较后,我们提出的分类算法使用更小的数据集和更少的训练特征产生了与其他最先进的分类算法相当的结果。临床相关性——这确立了将机器学习算法应用于从客观步态分析方法获得的基本步态数据在健康成人、老年人和帕金森患者分类中的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gait Classification of Parkinson’s Disease with Supervised Machine Learning Approach
Gait analysis is essential for diagnosis, assessment, monitoring purpose, and prediction of gait disorder. However, the objective analysis method is less feasible in hospital environments for treatment purposes due to limited coverage of sources. Thus, this study aims to develop a classification algorithm that can effectively classify subjects with relatively simplified temporal spatial gait data. This study employed several datasets acquired from PhysioNet containing subjects’ gait data of three classes. The training dataset contains a total of 48,318 instances of three target classes (young healthy adults, old healthy adults, and Parkinson’s disease patients). Two classification algorithms were developed: Support Vector Machine (SVM) classification algorithm and Artificial Neural Network (ANN). Preprocessing was performed to the original dataset which includes data cleaning, data normalization and new features generation. Next, fine-tuning on the manipulating hyperparameters was performed, and 10-fold cross validation was applied. The optimum configuration of SVM model can generate an accuracy of 93.01% and F1 score of 0.92 with 43 minutes of computational time. On the contrary, the optimum configuration ANN classifier generates an accuracy of 90.56% and F1 score of 0.89 with 112 minutes computational time. Conclusion: In conclusion, comparing both of the proposed classification algorithms, the SVM classifier is more effectively than ANN classifier as overall for the gait dataset used in this study. In addition, after compared with other state-of-the-arts of gait classification algorithms, our proposed classification algorithm produced comparable results with other state-of-arts using a smaller dataset with fewer training features. Clinical Relevance– This establishes the potential of apply machine learning algorithm on basic gait data obtained from the objective gait analysis method in classification of healthy adults, older adults, and Parkinson’s patient.
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