诺谢拉教学医院年龄和性别群体甲状腺疾病筛查

Hamzulla Khan, Fawad J Khan, Z. Khan, Naseer Ahmed, W. Khan
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引用次数: 0

摘要

背景:巴基斯坦28.7%的人口有不同程度的甲状腺肿。其中40%的结节表现为甲状腺机能亢进,基于低于正常值的促甲状腺激素(TSH)。本研究的目的是在一项以医院为基础的研究中,确定基于促甲状腺激素(TSH)的年龄和性别群体的甲状腺疾病筛查。患者和方法:本横断面研究于2019年3月至2020年1月在Nowshera的Qazi Hussain Ahmed医疗中心进行。其中男性167例(42.6%),女性225例(57.4%)。所有转到病理实验室测量TSH水平的患者,无论年龄和性别,均被纳入测量甲状腺功能亢进、低下或正常状态的发生率。排除标准为服用药物或补充碘的患者。数值变量如年龄和TSH值以Mean with SD、Median和range表示。采用推理统计和相关统计(χ 2、ANOVA、Mann-Whitney U检验和Spearman相关)来确定性别和年龄组间TSH值的差异。结果:患者平均年龄31+8.1岁。平均TSH为5.22+16.5 ng/ml。单因素方差分析(ANOVA)统计各年龄组TSH值差异不显著(p = 0.15)。Mann Whitney U检验证实,TSH的分布在不同性别类别中是相同的(p=0.001)。甲状腺功能亢进55例(14%),轻度甲状腺功能减退23例(5.9%),甲状腺功能减退30例(7.7%)。卡方检验显示,性别与甲亢、甲亢的关系分别有统计学意义(p= 0.18, p=0.8)。Spearman秩相关检验显示,甲状腺功能减退与年龄类别的增加呈轻度至中度负相关(p=0.88, r=-0.47),甲状腺功能亢进与年龄类别的增加呈中度上坡相关(p= 0.31, r=0.51),但又无统计学意义(p= 0.31, r=0.51)。结论:我们观察到我们的人群中TSH的分布是偏斜的。根据TSH值将甲状腺疾病分为甲亢和甲减。甲状腺功能减退(TSH<0.4)与年龄呈负相关。而年龄与甲亢呈正相关。而不同性别间甲状腺功能亢进和甲状腺功能减退没有明显的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Screening of thyroid disorders in age and gender groups in a teaching hospital of Nowshera
 Background: In Pakistan 28.7% of the population had some degree of goiter. Out of those 40% of the nodules behaved hyperthyroidism based on the lower-than-normal values of thyroid stimulating hormones (TSH). Present study was designed as to determine the screening of thyroid disorders on the basis Thyroid Stimulating Hormone (TSH) in age and gender groups in a hospital-based study. Patients and methods: This cross-sectional study was conducted in Qazi Hussain Ahmed Medical Complex Nowshera from March 2019 to Jan 2020. Total 392 cases, 167 (42.6%) males and 225 (57.4%) females were included. All patients referred to pathology laboratory for measurement of TSH levels irrespective of age and gender were included to measure incidence of hyper, hypo or euthyroid status. Exclusion criteria were patients taking medications or iodine supplementation. Numerical variables like age and TSH values were presented with Mean with SD, Median and range. Inferential statistics and correlation statistics (chi-Square, ANOVA, Mann-Whitney U test and Spearman correlation) were used to determine the difference of TSH values in gender and age groups. Results: Mean age of the patients was 31+8.1 years. Mean TSH was 5.22+16.5 ng/ml. The difference of TSH values in the age categories using one way ANOVA statistics was insignificant (p = 0.15). Mann Whitney U Test confirmed that the distribution of TSH is the same across the categories of gender (p=0.001). Total 55 (14%) patients were hyperthyroid, and 23 (5.9%) mild hypothyroid and 30 (7.7%) hypothyroid. Chi square test showed the relation of gender with hypo and hyperthyroidism as statistically isignificant ( p= 0.18, p=0.8) respectively. Spearman ranked correlation test showed a mild to moderate inverse correlation of hypothyroidism with increase in age categories (p=0.88, r=-0.47) and a moderate uphill correlation of hyperthyroidism with increase in age categories, again statistically insignificant (p= 0.31, r=0.51). Conclusion: We observed a skewed distribution of TSH in our population. On the basis of the TSH values the thyroid disorders were categorized in hyper and hypothyroidism. There was a negative correlation of Hypothyroidsim (TSH<0.4) with age. While a positive correlation of age was noted with hyperthyroidism. While no significant relationship of hyper or hypothyroidism was noted in gender groups.
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