摘要:肺癌发生的早期阶段

S. Janes
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引用次数: 0

摘要

肺癌是男性和女性最大的癌症杀手,在过去的50年里,生存率没有任何提高。为了降低肺癌的死亡率,我们需要更早地发现和治疗它,最好是在发展为全面侵袭性癌症之前的前浸润性癌症阶段。这将使我们能够及时开始治疗,增加治愈的机会,挽救生命。肺癌起源于侵袭前病变,但有趣的是,并非所有这些病变都会发展为癌症。我们相信,了解进展为浸润性癌症的病变和消失的病变之间的差异,将指导我们找到导致浸润性癌症形成的关键蛋白质和基因,或不适当地打开或关闭。我的演讲将概述一些研究,这些研究对肺癌的发展有了新的认识,并确定了能够准确预测病变最终是否会发展成癌症的新的生物标志物。我希望,这将使潜在的治疗能够针对那些有可能进展的病变的患者,并确定与癌症发展相关的关键基因和蛋白质,从而开启开发化学预防治疗方法来阻止癌症发展的可能性。引用格式:Samuel M. james。肺癌发生的早期步骤[摘要]。第五届AACR-IASLC国际联合会议论文集:肺癌转化科学从实验室到临床;2018年1月8日至11日;费城(PA): AACR;临床肿瘤杂志,2018;24(17 -增刊):1 - 5。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abstract IA05: Early steps in lung oncogenesis
Lung cancer is the biggest cancer killer of men and women, and there has been no improvement in survival over the last 50 years. To reduce the mortality of lung cancer, we need to both detect and treat it earlier, ideally at a preinvasive cancer stage before progression into full-blown invasive cancer. This would allow us to initiate treatment in a timely manner, increasing the chances of cure and saving lives. Lung cancers arise from preinvasive lesions but, interestingly, not all these lesions progress to cancer. We believe that understanding the differences between the lesions that progress to invasive cancer and those that disappear will direct us to the key proteins and genes that are mis-expressed, or inappropriately switched on or off, that lead to invasive cancer formation. My talk will outline studies that shed new understanding on how lung cancer develops and identify novel biological markers that accurately predict whether a lesion will eventually grow into a cancer. This, I hope, will enable targeting potential therapies to those patients with lesions that are likely to progress and identify the key genes and proteins associated with cancer development, thereby opening the possibility of developing chemoprophylactic therapeutic approaches to prohibit cancer development. Citation Format: Samuel M. Janes. Early steps in lung oncogenesis [abstract]. In: Proceedings of the Fifth AACR-IASLC International Joint Conference: Lung Cancer Translational Science from the Bench to the Clinic; Jan 8-11, 2018; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(17_Suppl):Abstract nr IA05.
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