泌尿科医生在卵巢癌减体积手术中的作用

G. Koritsiadis, Ilias Giannakodimos, Seferlis Miltiadis, Michalis Nomikos, G. Athanasopoulos, S. Papanikolaou, Thodoris Kouranos
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摘要

尽管在过去的十年中,晚期卵巢癌(OC)扩散到泌尿道被认为是手术的禁忌症,但肿瘤中心的进步试图实施这些根治性手术。为了获得最佳的细胞减少手术(CRS),泌尿科医生在这些手术中起着重要的作用。减体积手术的目的是通过消除肉眼可见的病变,实现受累器官的根治性切除。如果累及泌尿器官,患者的生存取决于肿瘤切除术后边缘无残留病变和术后梗阻的发生率。术前评估肿瘤进入泌尿道的程度或卵巢扩散引起的肾道扩张被认为是具有挑战性的。首先,泌尿科医生应该通过放置输尿管支架或肾造口管来减压下尿路。输尿管梗阻初步减压后,应进行泌尿外科手术,初步识别输尿管,重建输尿管病变。肿瘤侵袭膀胱的最佳CRS可通过根治性手术或保膀胱手术来实现。此外,泌尿科医生应该针对累及肾脏的晚期OC患者的手术管理、术前和术后评估。由于对这一主题的了解有限,目前尚无关于OC减积手术中泌尿器官手术入路的指南,而这些患者的手术治疗应遵循侵袭其他类型器官的晚期OC的处理指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of urologist in ovarian cancer debulking surgery
Although spread of advanced ovarian cancer (OC) into the urinary tract was considered a contraindication for surgery until the last decade, advancement of oncological centers tries to perform these radical surgeries. Urologist plays a significant role during these surgeries in order to obtain an optimal cytoreductive surgery (CRS). The aim of debulking surgeries is to achieve radical resection of involved organs by eliminating macroscopic disease. If urinary organs are involved, patients' survival depends on tumor resection with free postoperative margins and without residual disease and the incidence of postoperative obstruction. Preoperative evaluation of the extent of tumor into the urinary tract or dilation of the renal tract caused by ovarian spread is considered challenging. First, urologists should aim to the decompression of the lower urinary tract by placing either ureteral stents or nephrostomy tubes. After initial decompression of ureteral obstruction, urinary surgeries should follow aiming to initial identification of ureters and reconstruction of ureteral lesions. Optimal CRS in cases of OC invading the urinary bladder can be achieved either by radical or by bladder-sparing surgical procedures. Furthermore, urologists should aim to the surgical management, pre- and postoperative evaluation of patients with advanced OC involving the kidney. Due to restricted knowledge on this topic, there are no current guidelines concerning the surgical approach of urinary organs during debulking surgeries for OC, while surgical treatment of these patients should follow guidelines for the management of advanced OC invading other types of organs.
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