使用显示TAT的生物纳米胶囊的体内子宫局部基因传递系统

The Journal of Gene Medicine Pub Date : 2019-11-07 DOI:10.1002/jgm.3140

Kaori Koizumi, H. Nakamura, M. Iijima, T. Matsuzaki, Masaharu Somiya, K. Kumasawa, T. Kimura, S. Kuroda

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引用次数: 3

摘要

子宫是一个可以直接通过阴道途径进入的器官，而子宫的药物传递系统和基因传递系统(GDS)非常有限，即使在动物模型中也是如此。在本研究中，我们优化了一种包含乙型肝炎病毒包膜L蛋白颗粒的生物纳米胶囊(BNC)，其结构相似的颗粒已在全球范围内用作传统乙型肝炎疫苗的免疫原超过30年，用于小鼠模型的局部子宫GDS。

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In vivo uterine local gene delivery system using TAT‐displaying bionanocapsules

The uterus is an organ that is directly accessible via the transvaginal route, whereas the drug delivery system and the gene delivery system (GDS) for the uterus are very limited, even in animal models. In the present study, we optimized a bionanocapsule (BNC) comprising a hepatitis B virus envelope L‐protein particle, for which a structurally similar particle has been used as an immunogen of a conventional HB vaccine worldwide for more than 30 years, as a local uterine GDS using a mouse model.

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The Journal of Gene Medicine

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