Design-for-Reliability and Probability-Based Fault Tolerance for Paper-Based Digital Microfluidic Biochips with Multiple Faults

Paper-based digital microfluidic biochips (PB-DMFBs) have emerged as the most promising solution to biochemical applications in resource-limited regions. However, like silicon chips, the reliability of PB-DMFBs is affected by physical defects. Even worse, since electrodes, conductive wires, and droplet routings are entangled on the same layer, multiple faults may occur simultaneously. Such faults not only cause waste of samples and human resource but also affect the correctness of the diagnostics. In this paper, we propose a reliability scheme with emphasis on design-for-reliability (DfR) and probability-based fault tolerance to ensure the correct functionality of PB-DMFBs with multiple faults.