Serum Lipid Profiles in Patients with Systemic Lupus Erythematosus

1. Background: Systemic lupus erythematosus (SLE) is an autoimmune disease that involves multiple organ systems. Lipid profile is a panel of blood test that serves as an initial broad medical screening tool for abnormalities in lipid such as cholesterol and triacylglycerol. The result of this test can identify certain genetic diseases and can determine approximate risk for cardiovascular diseases, cerebrovascular diseases and certain form of pancreatitis and other diseases. Premature cardiovascular disease is the leading cause of morbidity in lupus which may be directly associated with altered lipid metabolism in systemic lupus erythematosus patient. Objective: To find out the relation of serum lipid profile with systemic lupus erythematosus patients. Methodology: This cross sectional study was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from January 2017 to December 2017. In this study, fifty diagnosed patients of SLE (Group A) and fifty apparently healthy individuals (Group B) of both sexes were selected according to the selection criteria from Department of Medicine, Dhaka medical college hospital, Dhaka (Group A) and by personal contact (Group B). Baseline parameters (body mass index, blood pressure and fasting plasma glucose) of both groups were measured. Serum lipid profile was estimated by enzyme immune assay, total cholesterol (TC), triglyceride (TG) and high density cholesterol (HDL-c) was estimated by enzymatic method. Results: Among the parameters of lipid profile serum TC, TG and LDL-C were significantly higher (p <0.001) in SLE patients than that of healthy individuals and serum HDL-C concentration was lower in SLE group than healthy group which highly significant. Correlation of SLE with serum TC, TG, LDL-C was significantly positive (p <0.001) and with HDL-c there was an inverse correlation which was significant (p<0.001). Conclusion: Serum lipid profile was significantly dysregulated in SLE patients. Moreover, .........