通过自动网织红细胞分析诱导治疗急性淋巴细胞白血病的造血功能恢复

Yesmin, A. Nesa, T. Sultana, C. Roy, Q. Rahman, A. Ahmed
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引用次数: 0

摘要

急性淋巴细胞白血病(ALL)是孟加拉国最常见的儿童恶性肿瘤。由于反应性高,ALL采用化疗治疗。化疗后可能发生感染,增加发育不全的时间。为此目的,需要进行可靠的实验室检查,以显示早期血液学恢复。目前,化疗后使用绝对中性粒细胞计数(ANC)、网织红细胞计数和外周血膜(PBF)检查来预测骨髓恢复。外周血样本中的网织红细胞定量,作为未成熟网织红细胞分数(lRF)的百分比或绝对计数,是许多研究建立的血液学恢复的可靠指标。本横断面研究是通过自动网织红细胞分析来评估ALL患儿的造血恢复情况。在缓解诱导期共入组50例患者。所有患者年龄在8个月~ 15岁之间,平均年龄5.5±3.2岁。在这项研究中,网织红细胞百分比的恢复发生在20天的中位数;ARC 18天;IRF 16天;HFR为18天,ANC中位数为23天。本研究证实,在各参数中,IRF恢复较早。关键词:未成熟网织细胞分数;高荧光网状细胞;低荧光网状细胞(LFR);中荧光网状细胞;绝对中性粒细胞计数(ANC);绝对网织红细胞计数(ARC)。DOI: http://dx.doi.org/10.3329/bjpath.v26i1.9128 BJPATH 2011;26 (1): 10 - 13
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Haematopoietic Recovery On Induction Therapy In Acute Lymphoblastic Leukaemia By Automated Reticulocyte Analysis
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy in Bangladesh. ALL is treated with chemotherapy due to high responsiveness. After chemotherapy infection may occur which increases the time of aplasia. For this purpose, reliable laboratory tests that will indicate early haematological recovery are needed. At present, absolute neutrophil count (ANC), reticulocyte counts and peripheral blood film (PBF) examination are used after chemotherapy for prediction of bone marrow recovery. Reticulocyte quantification in the peripheral blood samples, as a percentage or absolute count with immature reticulocyte fraction (lRF) are a reliable measure of haematological recovery established by many studies. This cross sectional study was carried out to evaluate the haematopoietic recovery in children with ALL by automated reticulocyte analysis. Total fifty patients were enrolled in this study on remission induction phase. They received the drugs of the protocol of UKALL-XI. All patients were between 8 months to 15 years age range with a mean age of 5.5 ±3.2. In this study the recovery of reticulocyte percentage occurred at a median of 20 days; ARC 18 days; IRF 16 days; HFR 18 days and ANC was obtained after a median of 23 days. This study established that among the various parameters IRF recovered earlier than others. Keywords: Immature Reticulocyte Fraction(lRF); High fluorescent reticulocyte (HFR); Low fluorescent reticulocyte (LFR); Middle fluorescent reticulocyte (MFR); Absolute neutrophil count (ANC); Absolute Reticulocyte count(ARC). DOI: http://dx.doi.org/10.3329/bjpath.v26i1.9128 BJPATH 2011; 26(1): 10-13
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