有无静脉造影剂不良反应患者ct检查血清总免疫球蛋白E水平的差异

Yulikha Ikhmawati, Z. Zubir, E. R. Daulay
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引用次数: 0

摘要

静脉造影剂(ICM)的不良反应(AR)比较常见。对ICM性AR的发病机制提出了不同的看法,怀疑免疫球蛋白E (IgE)在过敏性AR中的作用。目的:确定ICM性AR患者和非ICM性AR患者在CT扫描检查时血清总IgE水平的差异。观察ICM不良反应不同严重程度患者血清总IgE水平的差异。方法:采用横断面设计对104例接受ICM CT扫描的患者进行分析研究,检测ICM前后的IgE水平,并测定造影剂不良反应的严重程度。结果:本研究中出现不良反应的受试者,服用Iopamidol前平均IgE为1270.79 mg/dl高于服用AR组的1174.90 mg/dl;服用Iopamidol后,服用AR组的平均IgE为1507.96 mg/dl高于服用AR组的1325.88 mg/dl, p = 0.696,无统计学意义。轻度反应40例(38.5%),表现为咳嗽、恶心、头晕、瘙痒和出汗。结论:不良反应阳性受试者总IgE水平升高是独立的(p=0.696)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Difference in Total Serum Immunoglobulin E Level Among Patients With and Without Intravenous Contrast Media Adverse Reaction on Computed Tomography Scan Examination
The adverse reaction (AR) to intravenous contrast media (ICM) are relatively common. Various opinions pro-posed in the mechanism of the incidence of ICM AR. Suspected that the role of Immunoglobulin E (IgE) me-diates allergic conditions that are part of the AR. Objective:To determine the difference in total serum IgE level  among subjects with and without ICM AR on computed tomography (CT) scan examination. To ob-serve difference in total serum IgE levels in subjects undergoing ICM adverse reaction based on the degree of severity. Method: An analytical study with cross-sectional design of 104 subjects undergoing CT scans with ICM, examined IgE levels before and after ICM was administered, then measured the severity of adverse  re-actions of contrast media. Result: In this study, subjects undergoing adverse reactions, prior to administration Iopamidol  had a higher mean IgE 1270.79 mg / dl compared with those who having AR  1174.90 mg / dl and after administration of Iopamidol  a mean of Ig E is still higher in subjects having AR  1507.96 mg/dl com-pared with those having negative AR that is 1325.88 mg/dl, p = 0.696, statistically, not significant. Mild reac-tions in 40 subjects (38.5%) with cough, nausea, dizziness, itching, and sweating. Conclusion: Increase in total IgE levels in subjects with positive adverse reactions are independent(p=0.696).
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