基于rna的下一代测序在非小细胞肺癌(NSCLC)的集中模型中进行体细胞分子检测:现实世界数据表明是时候重新考虑检测选择了

A. Finall
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引用次数: 1

摘要

管理非鳞状、非小细胞肺癌患者的最佳实践包括一系列分子标记的体细胞检测。在英国,通过转诊到集中的基因组实验室中心,越来越多地使用基于rna的下一代测序来检测恶性肿瘤的可操作致癌驱动因素。最近的审计数据从作者的案例工作表明,RNA测序失败率为35%。本文考察了可能导致失败率的现实环境,并讨论了患者护理途径的替代方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
RNA-Based Next-Generation Sequencing in the Somatic Molecular Testing of Non-Small-Cell Lung Cancer (NSCLC) in a Centralized Model: Real-World Data to Suggest It Is Time to Reconsider Testing Options
Best practice in the management of non-squamous, non-small-cell lung cancer patients involves somatic testing for a range of molecular markers. Actionable oncogenic drivers of malignancy are increasingly being detected using RNA-based next-generation sequencing in the UK by referral to centralized genomic laboratory hubs. Recent audit data from the author’s case work have demonstrated an RNA sequencing failure rate of 35%. This article examines the real-world context, which may account for this failure rate, and discusses alternative options for patient care pathways.
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