DYSLIPIDEMIA AND BENIGN BREAST DISEASES

Background: Benign breast disorders are the most common abnormalities found in women as far as breast disease is concerned. The study's goal was to see if there is a link between serum dyslipidemia and benign breast diseases in women. Subjects and Methods: This is a case-control study, that involved 70 patients with benign breast diseases (cyclical mastalgia, fibrocystic breast disease and fibroadenoma) and 70 control healthy women and all of them had been selected randomly, aged (20-45 years) in a period between 1st September. 2021-30th June. 2022. It is hospital-based study, The patients’ group was carried out at the breast clinic at Azadi teaching hospital, while healthy participants in control group had been recruited in this study from different places in Duhok city such as governmental institutions, camps and universities with matching ages. Results: The mean age of patients and control groups was 33.5±7.6 and 33.1±6.5 respectively. Fibrocystic breast disease constitutes 40 % of patients with benign breast diseases, while 38 % of them had cyclical mastalgia and only 21% had fibroadenoma. Seventy-Eight percent of patients had a normal lipid profiles and it is also normal in 80 % of a control group (P value less than <0.8). There was a significant difference in total cholesterol and VLDL between patients and control groups (P value less than <0.004 and 0.0005 consequently). Regarding the relationship of a lipid profile to the different etiologies of benign breast diseases, all parameters were not significant between different groups except for LDL and VLDL, as it was significant when we compare fibroadenoma to fibrocystic breast diseases with the P-value of 0.0001 and 0.0002 consequently. Also, when we compare fibroadenoma and cyclical mastalgia, there was a significant difference between LDL and VLDL with P values of 0.0001 and 0.01consequently. Conclusion: There is a clear association between benign breast diseases and some parameters of lipid profile such as total cholesterol and VLDL. We do recommend measuring lipid profiles in these groups of patients especially those with fibroadenoma