非法使用氯胺酮的最新情况

P. Kleczkowska, M. Zaremba
{"title":"非法使用氯胺酮的最新情况","authors":"P. Kleczkowska, M. Zaremba","doi":"10.5772/intechopen.100644","DOIUrl":null,"url":null,"abstract":"Ketamine is a derivative of phencyclidine with unique anesthetic, analgesic, as well as antidepressant pharmacological properties. Despite its clinical use, ketamine is classified on the list with new psychoactive substances having psychedelic properties. The abuse trend of ketamine increasing globally, and it became a common club drug over the past few decades. Of note, recreational use of ketamine may pose a threat to public health, leading to numerous physical, as well as psychiatric negative effects. In addition, simultaneously or sequentially ketamine use with other drugs, resulting in serious health consequences. Currently, there are no specific treatment options for managing compulsive drug-seeking behavior in patients with ketamine use disorder, while the pharmacotherapy of side effects is limited and mostly symptomatic. In this chapter, we discuss ketamine abuse history. Further, we proposed the mechanisms of neural disinhibition underlying addiction development in ketamine-dependent patients. We have also included details of possible negative consequences focusing on long-term and recreational ketamine use for both, central and peripheral systems. Finally, we provide an overview of ketamine concomitant use and corresponding adverse interactions.","PeriodicalId":134765,"journal":{"name":"Ketamine Revisited - New Insights into NMDA Inhibitors [Working Title]","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"An Update of Ketamine Illicit Use\",\"authors\":\"P. Kleczkowska, M. Zaremba\",\"doi\":\"10.5772/intechopen.100644\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ketamine is a derivative of phencyclidine with unique anesthetic, analgesic, as well as antidepressant pharmacological properties. Despite its clinical use, ketamine is classified on the list with new psychoactive substances having psychedelic properties. The abuse trend of ketamine increasing globally, and it became a common club drug over the past few decades. Of note, recreational use of ketamine may pose a threat to public health, leading to numerous physical, as well as psychiatric negative effects. In addition, simultaneously or sequentially ketamine use with other drugs, resulting in serious health consequences. Currently, there are no specific treatment options for managing compulsive drug-seeking behavior in patients with ketamine use disorder, while the pharmacotherapy of side effects is limited and mostly symptomatic. In this chapter, we discuss ketamine abuse history. Further, we proposed the mechanisms of neural disinhibition underlying addiction development in ketamine-dependent patients. We have also included details of possible negative consequences focusing on long-term and recreational ketamine use for both, central and peripheral systems. Finally, we provide an overview of ketamine concomitant use and corresponding adverse interactions.\",\"PeriodicalId\":134765,\"journal\":{\"name\":\"Ketamine Revisited - New Insights into NMDA Inhibitors [Working Title]\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ketamine Revisited - New Insights into NMDA Inhibitors [Working Title]\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5772/intechopen.100644\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ketamine Revisited - New Insights into NMDA Inhibitors [Working Title]","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5772/intechopen.100644","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3

摘要

氯胺酮是苯环利定的衍生物,具有独特的麻醉、镇痛和抗抑郁药理特性。尽管临床上使用氯胺酮,但它被列为具有致幻剂特性的新型精神活性物质。氯胺酮的滥用趋势在全球范围内呈上升趋势,在过去几十年中,氯胺酮已成为一种常见的俱乐部毒品。值得注意的是,娱乐性使用氯胺酮可能对公众健康构成威胁,导致许多身体和精神方面的负面影响。此外,氯胺酮与其他药物同时或先后使用,造成严重的健康后果。目前,对于氯胺酮使用障碍患者的强迫性寻求药物行为,没有特定的治疗方案,而药物治疗的副作用是有限的,而且大多是症状性的。在本章中,我们讨论氯胺酮的滥用历史。此外,我们提出了氯胺酮依赖患者成瘾发展的神经去抑制机制。我们还详细介绍了长期和娱乐性氯胺酮使用对中枢和外周系统可能产生的负面影响。最后,我们提供氯胺酮伴随使用和相应的不良反应的概述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Update of Ketamine Illicit Use
Ketamine is a derivative of phencyclidine with unique anesthetic, analgesic, as well as antidepressant pharmacological properties. Despite its clinical use, ketamine is classified on the list with new psychoactive substances having psychedelic properties. The abuse trend of ketamine increasing globally, and it became a common club drug over the past few decades. Of note, recreational use of ketamine may pose a threat to public health, leading to numerous physical, as well as psychiatric negative effects. In addition, simultaneously or sequentially ketamine use with other drugs, resulting in serious health consequences. Currently, there are no specific treatment options for managing compulsive drug-seeking behavior in patients with ketamine use disorder, while the pharmacotherapy of side effects is limited and mostly symptomatic. In this chapter, we discuss ketamine abuse history. Further, we proposed the mechanisms of neural disinhibition underlying addiction development in ketamine-dependent patients. We have also included details of possible negative consequences focusing on long-term and recreational ketamine use for both, central and peripheral systems. Finally, we provide an overview of ketamine concomitant use and corresponding adverse interactions.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信