Personalized rehabilitation of patients with psychostimulant addiction, taking into account the polymorphism of genes controlling the serotonin system and neuroplastic brain processes

The relevance of this study is due to the annual increase in patients with psychostimulant addiction and the lack of evidence-based methods of their rehabilitation within the framework of a personalized approach that takes into account the state of pathogenetic biomarkers of the disease. The aim of the study is to develop a personalized approach to the rehabilitation of patients with psychostimulant addiction, taking into account the polymorphism of genes controlling the work of the serotonin system and neuroplastic processes of the brain. As a result of the study of 325 patients with psychostimulant addiction, polymorphic variants of genes controlling the work of the serotonin system (SLC6A4, HTR2A, HTR2C) and neuroplastic brain processes (BDNF), affecting the formation of dependence and the effectiveness of therapy, were identified. It has been established that polymorphisms in these genes are associated with the effectiveness of motivational work for the rehabilitation program of patients with psychostimulant addiction and the duration of remissions. Based on the results obtained, personalized profiles of patients with psychostimulant addiction, taking into account certain clinical and genetic biomarkers and features of the response of patients to motivational psychotherapy aimed at rehabilitation and the formation of long-term remission, were identified.