体外振动多向超声剪切波弹性成像(EVMUSE)

Heng Zhao, P. Song, Duane D. Meixner, R. Kinnick, M. Callstrom, William Sanchez, M. Urban, A. Manduca, J. Greenleaf, Shigao Chen
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引用次数: 1

摘要

横波速度可用于评估组织弹性,这与组织健康有关。超声剪切波弹性成像技术基于测量由声辐射力引起的剪切波的传播速度,正在成为肝纤维化分期活检的有希望的替代方法。然而,这种方法产生的横波通常非常弱。因此,插入可能会出现问题,特别是对于超重或肥胖患者。在这项研究中,我们开发了一种名为外部振动多向超声剪切波弹性成像(EVMUSE)的新方法,该方法利用扬声器的外部振动来产生多向剪切波场。然后利用方向滤波器将复杂的横波场分离成几个在不同方向上传播的横波场。从每个单独的横波场重建二维横波速度图,并将这些单独的波速图组合成最终的二维横波速度图。采用两个均匀型和一个多用途型模型对该方法进行了验证。同时对10例肝脏磁共振弹性成像(MRE)患者进行EVMUSE研究,比较两种方法的结果。幻影结果显示,EVMUSE能够准确量化组织弹性,穿透性好。体内EVMUSE结果与MRE结果具有良好的相关性,表明使用EVMUSE进行肝纤维化分期的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Liver elasticity imaging using external Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE)
Shear wave speed can be used to assess tissue elasticity, which is associated with tissue health. Ultrasound shear wave elastography techniques based on measuring the propagation speed of the shear waves induced by acoustic radiation force are becoming promising alternatives to biopsy in liver fibrosis staging. However, shear waves generated by such methods are typically very weak. Therefore, the penetration may become problematic, especially for overweight or obese patients. In this study, we developed a new method called External Vibration Multi-directional Ultrasound Shearwave Elastography (EVMUSE), in which external vibration from a loudspeaker was used to generate a multi-directional shear wave field. A directional filter was then applied to separate the complex shear wave field into several shear wave fields propagating in different directions. A two-dimensional (2D) shear wave speed map was reconstructed from each individual shear wave field, and a final 2D shear wave speed map was constructed by compounding these individual wave speed maps. The method was validated using two homogeneous phantoms and one multi-purpose phantom. Ten patients undergoing liver Magnetic Resonance Elastography (MRE) were also studied with EVMUSE to compare results between the two methods. Phantom results showed EVMUSE was able to quantify tissue elasticity accurately with good penetration. In vivo EVMUSE results were well correlated with MRE results, indicating the promise of using EVMUSE for liver fibrosis staging.
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