{"title":"利用动态规划对DNA序列进行比对","authors":"E. Rouchka","doi":"10.1145/1217666.1217675","DOIUrl":null,"url":null,"abstract":"DNA can be thought of as a four-letter alphabet with the symbols A, C, G, and T representing the four possible nucleotides: adenine, cytosine, guanine, and thymine. The genome of an organism is composed of a linear sequence of A, C, G, and T that can be decoded from an individual's chromosomes. For the human genome, this is on the order of 3.2 billion bases. Within a genome, special sets of instructions known as genes code for proteins that provide structural and functional properties. Inside of a gene-coding region, every three bases codes for an amino acid. Since there are four possibilities for each position (A, C, G, or T), there are 4 * 4 * 4 = 64 potential three-base patterns, or codons.","PeriodicalId":429016,"journal":{"name":"ACM Crossroads","volume":"13 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2006-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Aligning DNA sequences using dynamic programming\",\"authors\":\"E. Rouchka\",\"doi\":\"10.1145/1217666.1217675\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"DNA can be thought of as a four-letter alphabet with the symbols A, C, G, and T representing the four possible nucleotides: adenine, cytosine, guanine, and thymine. The genome of an organism is composed of a linear sequence of A, C, G, and T that can be decoded from an individual's chromosomes. For the human genome, this is on the order of 3.2 billion bases. Within a genome, special sets of instructions known as genes code for proteins that provide structural and functional properties. Inside of a gene-coding region, every three bases codes for an amino acid. Since there are four possibilities for each position (A, C, G, or T), there are 4 * 4 * 4 = 64 potential three-base patterns, or codons.\",\"PeriodicalId\":429016,\"journal\":{\"name\":\"ACM Crossroads\",\"volume\":\"13 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACM Crossroads\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1145/1217666.1217675\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACM Crossroads","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1145/1217666.1217675","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DNA can be thought of as a four-letter alphabet with the symbols A, C, G, and T representing the four possible nucleotides: adenine, cytosine, guanine, and thymine. The genome of an organism is composed of a linear sequence of A, C, G, and T that can be decoded from an individual's chromosomes. For the human genome, this is on the order of 3.2 billion bases. Within a genome, special sets of instructions known as genes code for proteins that provide structural and functional properties. Inside of a gene-coding region, every three bases codes for an amino acid. Since there are four possibilities for each position (A, C, G, or T), there are 4 * 4 * 4 = 64 potential three-base patterns, or codons.
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