J Garduño Espinosa, R Paniagua Sierra, S Díaz Bensussen, A Lifshitz
{"title":"慢性肝损伤大鼠血清锌、铜对炎症刺激的反应。","authors":"J Garduño Espinosa, R Paniagua Sierra, S Díaz Bensussen, A Lifshitz","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective of the study: </strong>To measure the seric levels of zinc and copper in healthy and in hepatic damaged rats when an inflammatory stimulus is applied.</p><p><strong>Research design: </strong>2 x 2 factorial design.</p><p><strong>Subjects: </strong>Fisher *44 strain rats, healthy and with chronic hepatic damage.</p><p><strong>Measurements: </strong>Serum levels of Zn and Cu were determined in the different experimental conditions.</p><p><strong>Results: </strong>Basal Zn levels were found diminished in rats with hepatic damage as compared with healthy ones (p < 0.05), whereas Cu levels were found increased in hepatic damaged rats as compared with healthy ones (p < 0.05). Application of an inflammatory stimulus decreased Zn and increased Cu levels in healthy rats as compared to their basal conditions (p < 0.05), whereas no statistically significant variations were found in the group of rats with hepatic damage when comparing their serum levels before and after inflammatory stimulation.</p><p><strong>Conclusions: </strong>Rats with liver damage present alterations in their Zn and Cu levels under basal conditions. Rats with liver damage, submitted to an inflammatory stimulus, do not modify their serum Zn and Cu levels.</p>","PeriodicalId":75554,"journal":{"name":"Archivos de investigacion medica","volume":"22 3-4","pages":"289-94"},"PeriodicalIF":0.0000,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Response of serum zinc and copper to inflammatory stimulation in the rat with chronic liver damage.\",\"authors\":\"J Garduño Espinosa, R Paniagua Sierra, S Díaz Bensussen, A Lifshitz\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective of the study: </strong>To measure the seric levels of zinc and copper in healthy and in hepatic damaged rats when an inflammatory stimulus is applied.</p><p><strong>Research design: </strong>2 x 2 factorial design.</p><p><strong>Subjects: </strong>Fisher *44 strain rats, healthy and with chronic hepatic damage.</p><p><strong>Measurements: </strong>Serum levels of Zn and Cu were determined in the different experimental conditions.</p><p><strong>Results: </strong>Basal Zn levels were found diminished in rats with hepatic damage as compared with healthy ones (p < 0.05), whereas Cu levels were found increased in hepatic damaged rats as compared with healthy ones (p < 0.05). Application of an inflammatory stimulus decreased Zn and increased Cu levels in healthy rats as compared to their basal conditions (p < 0.05), whereas no statistically significant variations were found in the group of rats with hepatic damage when comparing their serum levels before and after inflammatory stimulation.</p><p><strong>Conclusions: </strong>Rats with liver damage present alterations in their Zn and Cu levels under basal conditions. Rats with liver damage, submitted to an inflammatory stimulus, do not modify their serum Zn and Cu levels.</p>\",\"PeriodicalId\":75554,\"journal\":{\"name\":\"Archivos de investigacion medica\",\"volume\":\"22 3-4\",\"pages\":\"289-94\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos de investigacion medica\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos de investigacion medica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Response of serum zinc and copper to inflammatory stimulation in the rat with chronic liver damage.
Objective of the study: To measure the seric levels of zinc and copper in healthy and in hepatic damaged rats when an inflammatory stimulus is applied.
Research design: 2 x 2 factorial design.
Subjects: Fisher *44 strain rats, healthy and with chronic hepatic damage.
Measurements: Serum levels of Zn and Cu were determined in the different experimental conditions.
Results: Basal Zn levels were found diminished in rats with hepatic damage as compared with healthy ones (p < 0.05), whereas Cu levels were found increased in hepatic damaged rats as compared with healthy ones (p < 0.05). Application of an inflammatory stimulus decreased Zn and increased Cu levels in healthy rats as compared to their basal conditions (p < 0.05), whereas no statistically significant variations were found in the group of rats with hepatic damage when comparing their serum levels before and after inflammatory stimulation.
Conclusions: Rats with liver damage present alterations in their Zn and Cu levels under basal conditions. Rats with liver damage, submitted to an inflammatory stimulus, do not modify their serum Zn and Cu levels.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
