海苔醇提物对动物病原菌的抗真菌活性研究

Adrian Srikishen, Gomathinayagam Subramanian
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引用次数: 1

摘要

病原真菌对正常抗真菌药物的抗性增加导致其治疗真菌疾病的有效性下降。因此,迫切需要新的治疗形式,这导致对传统药物,特别是草药性质的研究。海苔就是这样一种植物,历史上一直被用于草药治疗各种疾病,其中许多是真菌病原体造成的。因此,本研究的重点是确定海苔叶酒精提取物对两种动物病原体的抗真菌效果。分别以50%、10%、5%和1%的浓度制备海参叶粗醇提取物。然后用孔扩散法对黄曲霉和马拉色菌进行抗真菌测定。结果表明,10% 5%和1%提取物对黄曲菌的抑制区分别为55.9±3.40 mm、52.7±1.72 mm和47.0±3.68 mm;当提取液浓度为50%时,无抑制作用。当提取物浓度为50%时,对马拉色菌的抑制作用为25.3±5.44 mm,较低浓度时无抑制作用。因此,从这些发现可以看出,海苔叶酒精提取物对黄芽孢杆菌有效,而对马拉色菌的效果较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antifungal activity of alcoholic extracts of Batis maritima against animal pathogens
The increase in resistance of pathogenic fungi towards normal antifungals has led to a decrease in their effectiveness in the treatment of fungal diseases. Therefore, the need for newer forms of treatment is urgent, leading to studies into traditional medicines, specifically those of herbal natures. Batis maritima is one such plant, which has historically been used in herbal remedies for the treatment of a wide range of diseases, many of which are results of fungal pathogens. The focus of this study was therefore to determine the effectiveness of alcoholic extract of leaves of B. maritima as an antifungal agent against two animal pathogens. Crude alcoholic extracts of leaves of B. maritima were prepared in concentrations of 50%, 10% 5% and 1%. These were then subjected to antifungal assays against Aspergillus flavus and Malassezia sp., using the Well Diffusion method. The results of the tests showed Zones of Inhibition of 55.9 ± 3.40 mm, 52.7 ± 1.72 mm and 47.0 ± 3.68 mm, respectively, for the 10% 5% and 1% extracts against A. flavus; no inhibition was seen with the 50% extract concentration. With respect to Malassezia sp., inhibition of 25.3 ± 5.44 mm was observed at 50% extract concentration, with no inhibition at lower concentrations. It may therefore be seen from these findings that alcoholic leaf extracts of B. maritima prove to be effective against A. flavus while lesser effective against Malassezia sp.
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