T峰端间隔对急性心肌梗死后危险分层的预后价值

IF 0.3 Q4 CRITICAL CARE MEDICINE
Tarek Mohamed Abdelrahman
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Little is known about its use for identifying risk of arrhythmias in acute myocardial infarction and this must be approached with great caution and require careful validation.</p></div><div><h3>Methods</h3><p>A prospective analysis of data from 564 patients admitted to our CCU by acute myocardial infarction along a period of two years from January 2012 to December 2013 was done. After exclusion of valvular, congenital lesions, HOCM, IDCM, pericardial diseases, accessory pathway, any Bundle branch block, metabolic disorders and re-perfusion arrhythmia. Analysis of TpTe interval and its dispersion were done for all patients and a Holter-24<!--> <!-->h was performed after one month. Patients were then classified into two groups based on Lown grading score for arrhythmia: group (I) (441 patients) with no or minimal arrhythmias (Lown score &lt;3), and group (II) (123) with high grade arrhythmias (Lown score ⩾3). 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引用次数: 6

摘要

致死性心律失常是急性心肌梗死患者入院或出院后猝死的主要原因。我们的目的是通过使用简单的床边心电图测试来确定心律失常死亡率高的人群。背景ST段抬高型心肌梗死患者的壁间复极弥散(TDR)是心律失常的主要触发因素。测量T波峰端间隔的电位值(Tpeak-Tend, Tp-Te)作为复极空间弥散度的指标,被认为是能够反映复极弥散度的参数,因此可能是检测心律失常风险的预后工具。目前对其用于识别急性心肌梗死中心律失常风险的用途知之甚少,因此必须非常谨慎,并需要仔细验证。方法前瞻性分析2012年1月至2013年12月我院CCU收治的564例急性心肌梗死患者资料。排除瓣膜、先天性病变、HOCM、IDCM、心包疾病、副通路、束支阻滞、代谢紊乱和再灌注心律失常后。对所有患者进行tpt间期及弥散度分析,并于1个月后进行Holter-24 h检测。然后根据心律失常的low评分将患者分为两组:没有或最小心律失常(low评分<3)的组(I)(441名患者)和具有高级别心律失常(low评分大于或小于3)的组(II)(123)。所有患者出院前均行超声心动图检查左心室功能及是否存在心肌动脉瘤。对心电信号进行平均,检测低幅值信号。所有患者均行出院前冠状动脉造影。结果统计分析结果显示,(II)组患者携带的肥胖、糖尿病和高血压患者数量明显增加。该组大多数患者为吸烟者,肌酐水平较高,且既往脑损伤暴露值明显高于(I)组。此外,(II)组患者需要的利尿剂和acei剂量明显高于(I)组。(II)组前壁梗死百分比明显高于(I)组,(I)组对下壁的影响更大。两组间的tpt间隔时间和离散度显示:(II)组tpt间期高于(I)组,与(I)组相比,这与猝死或恶性室速和左室功能恶化的发生有关。此外,(II)组暴露于再梗死和心源性休克的患者具有统计学意义(P <结论tpte与SCD发生率升高、左室功能恶化及心肌动脉瘤发生相关。它与LAS的存在高度相关,并与冠状动脉病变的严重程度相关。tpt间期和离散度延长的患者有可能发生致命性心律失常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic value of T peak-to-end interval for risk stratification after acute myocardial infarction

Aim

Fatal arrhythmia is the main cause of sudden death in patients with acute myocardial infarction either during hospital admission or in post-discharge period. Our aim is to identify groups at high risk of arrhythmic mortality by using a simple bed-side test in electrocardiogram.

Background

Trans-mural dispersion of repolarization (TDR) in patients with ST elevation myocardial infarction is the main trigger of arrhythmias. The potential value of measuring the interval between the peak and end of the T wave (Tpeak-Tend, Tp-Te) as an index of spatial dispersion of repolarization is a parameter thought to be capable of reflecting dispersion of repolarization and thus may be prognostic tool for detection of arrhythmic risk. Little is known about its use for identifying risk of arrhythmias in acute myocardial infarction and this must be approached with great caution and require careful validation.

Methods

A prospective analysis of data from 564 patients admitted to our CCU by acute myocardial infarction along a period of two years from January 2012 to December 2013 was done. After exclusion of valvular, congenital lesions, HOCM, IDCM, pericardial diseases, accessory pathway, any Bundle branch block, metabolic disorders and re-perfusion arrhythmia. Analysis of TpTe interval and its dispersion were done for all patients and a Holter-24 h was performed after one month. Patients were then classified into two groups based on Lown grading score for arrhythmia: group (I) (441 patients) with no or minimal arrhythmias (Lown score <3), and group (II) (123) with high grade arrhythmias (Lown score ⩾3). In-hospital predischarge echocardiography was done for all patients to evaluate left ventricular functions and presence of myocardial aneurysm. Signal average ECG was done to detect low amplitude signals (LAS). Pre-discharge coronary angiography was done for all patients.

Results

Statistical analysis of the results revealed that, group (II) patients carry a significantly higher number of obese, diabetic, and hypertensive patients. Most of patients in this group were smokers, having higher creatinine levels, and exposed previously to cerebral insults in significantly higher values than group (I). Also, group (II) patients need significantly higher doses of diuretic and ACEIs than group (I). The percentage of anterior wall infarction is significantly higher in group (II), with higher inferior wall affection in group (I). TpTe interval and dispersion between both groups revealed that, a higher TpTe interval was found in group (II) than group (I) and this was linked to occurrence of sudden death or malignant VT and deterioration in Lv functions than in group (I). Also, patients in group (II) exposed to re-infarction and cardiogenic shock in statistically significant values (P < 0.01) than group (I).

Conclusion

TpTe was significantly and independently associated with increased odds of SCD and is linked to deterioration of Lv functions and myocardial aneurysms. It's highly correlated to presence of LAS and associate with severity of coronary lesions. Patients with prolonged TpTe intervals and dispersions were likely to develop fatal arrhythmias.

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来源期刊
自引率
0.00%
发文量
5
审稿时长
42 weeks
期刊介绍: The Egyptian Journal of Critical Care Medicine is the official Journal of the Egyptian College of Critical Care Physicians, the most authoritative organization of Egyptian physicians involved in the multi-professional field of critical care medicine. The journal is intended to provide a peer-reviewed source for multidisciplinary coverage of general acute and intensive care medicine and its various subcategories including cardiac, pulmonary, neuro, renal as well as post-operative care. The journal is proud to have an international multi-professional editorial board in the broad field of critical care that will assist in publishing promising research and breakthrough reports that lead to better patients care in life threatening conditions, and bring the reader a quick access to the latest diagnostic and therapeutic approaches in monitoring and management of critically ill patients.
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