基于GP装置的血凝块行为CFD模拟

K. Kushaari, A. Rahman, G. Pearce
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引用次数: 3

摘要

仅在英国,每年就有13万例中风患者,导致患者死亡或严重残疾。近年来的进步使得使用机械取栓装置进行凝块提取成为可能。在本文中,我们提出了这种提取装置的模型,并研究了这种模型在预测设备在给定条件下的行为方面的价值。采用流体体积(Volume of Fluid, VOF)模型,采用不同网格尺寸的CFD模拟方法,对塑料动脉导管三维血凝块进行了模拟研究。网格尺寸研究表明,网格尺寸越小(网格越细),仿真输出结果的精度越高。值得注意的是,当单元格数量的进一步增加不会对模拟结果产生不利影响时,网格独立性得以实现,最佳网格大小避免了具有大量单元格的模拟所需的任何不必要的延长计算工作量。从网格尺寸研究的结果可以看出,0.3网格已经达到了它的渐近水平。相信它可以正确预测设备内的血块变形和血流。在这项研究中使用的所有压力都能够去除血凝块。结果表明,施加的压力越高,去除速度越快。当施加不同的压力时,还观察到不同的变形模式。结果发现,在本工作压力范围内,当施加60kpa的吸入压力时,最快清除血凝块的时间为0.006 s。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CFD Simulation of Blood Clot Behaviour Using GP Device
There are 130,000 strokes in the UK alone each year, causing death or servere disability to those who are affected. Advances in recent times have enabled clot extraction to be undertaken using mechanical thrombectomy devices. In this paper we present a model of such an extraction device, and investigate the value of such modelling in predicting the behaviour of the device under given conditions. A 3-dimensional blood clot simulation associated with a plastic arterial catheter is studied by applying CFD simulations with different size of grid, using the Volume of Fluid (VOF) model. Grid size study shows that the smaller grid size (finer mesh) results in higher accuracy of the output result of the simulation. It is noted that grid independency is achieved when any further increase in the number of cells did not adversely affect the simulation results, the optimum grid size avoided any unnecessary prolonged computational effort required for the simulations with large number of cells. From the results obtained in the grid size study, it can be concluded that mesh 0.3 has reached its asymptotic level. It is believed that it can predict the right clot deformation and blood flow in the device. All the pressures used in this study are able to remove the blood clot. It is found that the higher the pressure applied the faster the removal. Different deformation patterns are also observed when different pressures are applied. It is found that the fastest time to remove the blood clot with the range of pressure used in this work is 0.006 s, when 60 kPa of suction pressure is applied.
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