专门用于模拟人体血液动力学的多种控制和调节的软件

R. Grygoryan, O. Yurchak, A. Degoda, T. Lyudovyk
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引用次数: 3

摘要

大多数人体血流动力学模型只描述了直接或间接改变心脏泵活动和血管张力的生理机制的一小部分。因此,使用这些模型可以解决与心血管生理学相关的非常狭窄的任务范围。为了从本质上扩大这个范围,我们创建了基于机制定量模型的特殊软件,以提供循环的整体控制。在复杂模型中,在稳定的血容量和心血管参数值下提供的多室室血流动力学集总参数模型构成核心模型。它由两个心室和21个血管室组成。其他动态模型包括机械受体反射、化学受体反射、血管紧张素- ii、抗尿激素、血管加压素、肾上腺素和心脏或脑缺血的主要作用机制。该软件有一个面向生理学家的用户界面。它为研究者提供了模拟每个包含机制的不同状态的多种功能。该接口还允许创建所选机制的任意组合。特别地,这些机制的选定模型是通过用户界面激活或停用的。激活的模型调节核心模型的初始值。为模拟关于动脉性高血压病因学的不同假设创造了特殊的机会。仿真结果以图形形式给出。用户界面将每个模拟记录为一个特殊文件,可以保存以供以后独立分析。该软件是在。net技术框架下创建的,是一个独立的。exe文件,用于在PС上执行。软件也是一种很好的用于教育目的的计算机程序,可以向医学生说明主要的生理和某些病理规律。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Specialized software for simulating the multiple control and modulations of human hemodynamics
Most models of human hemodynamics describe only a small part of physiological mechanisms that directly or indirectly alter activities of the heart pump and vascular tones. Therefore, a very narrow range of tasks related to cardiovascular physiology can be solved using these models. To essentially widen this range, special software based on quantitative models of mechanisms providing the overall control of circulation is created. In the complex model, a multi-compartmental lumped parametric model of hemodynamics, provided under stable values of blood volume and cardiovascular parameters, forms the core model. It consists of two ventricles and 21 vascular compartments. Additional dynamic models represent mechanisms of mechanoreceptor reflexes, chemoreceptor reflexes, main effects of angiotensin-II, antidi uretic hormone, vasopressin, adrenalin, and cardiac or brain ischemia. The software has a physiologist-oriented user interface. It provides the investigator with multiple capabilities for simulating different states of each included mechanism. The interface also allows creating arbitrary combinations of the chosen mechanisms. In particular, the chosen model of these mechanisms is activated or deactivated via the user interface. The activated model modulates initial values of the core model. Special opportunities have been created for simulating different hypotheses concerning the etiology of arterial hypertension. Simulation results are presented with graphs. The user interface documents each simulation as a special file that can be saved for later independent analysis. The software, created in the frame of .NET technology, is an autonomous .EXE file for executing on PС. Software is also a good computer program to be used for educational purposes for illustrating the main physiological and certain pathological regularities to medical students.
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