基于s系统模型的遗传网络混合群体智能

W. Yeh, Chia-Ling Huang
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引用次数: 0

摘要

从观察到的基因表达模式的时间序列数据的潜在遗传网络中得出的任何推论的重要性都不应被忽视。它们是生物信息学中最大的课题之一。s系统模型是分析这种遗传网络的一个很好的选择,因为它可以捕获各种动态。该模型面临的一个问题是s系统参数的数量与基因数量的平方成正比。这也是为什么s系统模型倾向于在较小规模上使用的原因。采用混合软计算对其参数进行优化。此外,它还使用问题分解策略来处理系统可能面临的大量问题。首先,原始问题被分成几个较小的部分,然后由SSO分别解决。然后,将所有这些独立的解决方案合并在一起,并与ABC一起用于解决原始问题。这表明单点登录在解决此类子问题方面是有效的。最后,SSO还利用了混合软计算系统,这推断了在更大范围内拥有s系统的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The hybrid swarm intelligence for S-system model-based genetic network
The importance of any inferences that can be taken from underlying genetic networks of observed time-series data of gene expression patterns should not be overlooked. They are one of the largest topics within bioinformatics. The S-system model is one good choice for analyzing such genetic networks due to the fact that it can capture various dynamics. One problem this model faces is the fact that the number of S-system parameters is in proportion with the square of the number of genes. This is also the reasoning as to why the S-system model tends to be used on smaller scales. Its parameters are optimized by hybrid soft computing. Furthermore, it also uses the problem decomposition strategy to deal with the vast amount of problems a system might face. First of all the original problem is split into several smaller parts, which are then separately solved by the SSO. Afterwards, all of these separate solutions are merged together and used to solve the original problem along with the ABC. This shows the effectiveness of the SSO in solving such sub problems. Lastly, the SSO also utilizes the hybrid soft computing system, which infers the possibility of having S-systems on a larger scale.
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