自由基的ESR剂量测定——高强度超声场与电离Cs/sup 137源的比较

2000 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.00CH37121) Pub Date : 2000-12-01 DOI:10.1109/ULTSYM.2000.921575

J. Jenne, M. Moosmann, I. Simiantonakis, R. Rastert, P. Huber, M. Rheinwald, T. Haase, J. Debus

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引用次数: 1

摘要

高强度超声场有可能在水溶液中产生由惯性空化引起的自由基。在这项研究中，我们比较了在不同的超声模式下自由基的产生与在一个众所周知的Cs/sup 137/ γ射线源场中的自由基形成。此外，我们还考察了光动力物质对自由基产生的促进作用。用ESR光谱仪对自由基形成进行了分析。用高强度聚焦超声(HIFU)和驻波模式下的非聚焦超声场对溶液/空气界面进行超声检测。我们能够评估光子场和美国场中自由基发展的数量。比较超声和光子辐照确定等效剂量值是可行的。光敏剂对自由基产生的显著增强作用仅在驻波模式下的非聚焦超声场中检测到。

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ESR dosimetry of free radicals-a comparison between high intensity ultrasound fields and an ionizing Cs/sup 137/ source

High intensity ultrasound fields have the potential to produce free radicals in aqueous solutions caused by inertial cavitation. In this study we compared the production of free radicals under different sonication modalities with radical formation in the field of a well known Cs/sup 137/ gamma-ray source. In addition we examined the enhancement of radical production by photodynamic substances. Analysis of radical formation was performed with an ESR spectrometer. Sonication of aqueous test solution was carried out with high intensity focused ultrasound (HIFU) and with an unfocused ultrasound field in a standing wave mode against a solution/air interface. We were able to assess the quantity of free radicals developing in photon field as well as in US fields. It was feasible to determine equivalent dose values comparing ultrasound with photon irradiation. A significant enhancement of radical production by a photosensitizer was only detected in the unfocused ultrasound field in a standing wave mode.

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来源期刊

2000 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.00CH37121)

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