NTRK Fusion-Positive Congenital Spinal Glioblastoma treated with Carboplatin, Etoposide, and Larotrectinib

Introduction Primary spinal glioblastoma multiforme (GBM) is a rare central nervous system tumor accounting for less than 3% of pediatric central nervous system tumors. The congenital form of this malignancy is even more unusual. Here we present a case of a newborn diagnosed at birth with an advanced spinal cord congenital glioblastoma and successfully treated with etoposide/carboplatin chemotherapy and Larotrectinib. Case Description The patient was born full term via induced vaginal delivery due to decreased fetal movement. She was noted to have decreased tone in the delivery room, with a postured right arm; MRI of the brain and spine revealed an infiltrative mass in …