基于蛋白质的生物纳米物联网智能电路用于肾损伤的分子诊断

H. Nieto-Chaupis
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引用次数: 0

摘要

结果表明,足细胞周围白蛋白的积累与R-C(电阻-电容)电路非常相似。虽然电屏蔽不足以阻止白蛋白的通过,而不仅仅是一种扩散现象,但这是一个完全属于经典电动力学的问题。通过这种方法,确定了扩散常数作为电参数起作用。白蛋白的永久聚集产生电容。因此,R-C回路的能量消耗被解释为肾小球能量的损失,影响肾脏的功能和体内平衡。因此,电不平衡的识别被翻译为肾脏疾病的信号。基于物理的场景要求我们在生物纳米物联网的框架内提出方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Proteins-Based Circuits in an Intelligent Internet of Bio-Nano Things Network for Molecular Diagnostic of Renal Damage
It is shown that the accumulation of albumin proteins around the locations of podocytes is rather similar to a R-C (Resistance-Capacitor) circuit. While the electric shielding is not enough to detain the pass of albumin, more than a diffusion phenomenon, it is a problem that is entirely treated as one belonging to the classical electrodynamics. In this manner it was identified that the diffusion constant plays a role as the electrical parameters. The permanent aggregation of albumin proteins creates a capacitance. Therefore the expended power by the R-C circuit is interpreted as the loss of energy of renal glomerulus with implications on the performance and homeostasis of kidney. Thus, the identification of electric unbalance is translated as a signal of Kidney disease. The fact of having a physics-based scenario demands us to propose schemes inside the framework of the Internet of Bio-Nano Things.
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