风险

Scott Jackson, Ricardo Moraes dos Santos
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引用次数: 0

摘要

作为斯坦福MDS中心主任,格林伯格博士积极从事骨髓增生异常综合征(MDS)和克隆性骨髓疾病的临床实践。他的临床研究包括设计和协调临床试验,使用具有生物学重点的实验性药物,用于对标准治疗无反应的低风险和高风险MDS患者。他是MDS预后国际工作组(IWG-PM)的协调员,该工作组制定了修订的MDS分类系统(IPSS-R)和分子突变对基于风险的预后系统IPSS-Molecular (IPSS-M)的影响。他是NCCN MDS实践指南小组的主席。他之前的实验室研究包括MDS相关骨髓祖细胞增殖的生物学研究,以及影响MDS预后的基因表达谱的突变和转录组学评估。他目前的研究包括评估体外药物敏感性方法,以确定对标准治疗难治的髓系肿瘤患者可能有用的和经常新颖的治疗药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk
As Director of the Stanford MDS Center, Dr Greenberg has an active clinical practice focusing on myelodysplastic syndromes (MDS) and clonal myeloid disorders. His clinical research involves design and coordination of clinical trials using experimental drugs with biologic focus for both lower and higher risk MDS patients not responding to standard therapies. He is Coordinator of the International Working Group for Prognosis in MDS (IWG-PM) which generated the revised MDS classification system (the IPSS-R) and the impact of molecular mutations for a risk-based prognostic system, the IPSS-Molecular (IPSS-M). He is Chair of the NCCN Practice Guidelines Panel for MDS. His prior laboratory investigations included biologic studies of MDS-related myeloid progenitor cell proliferation as well as mutational and transcriptomic evaluation of gene expression profiles contributing to prognosis in MDS. His current investigations include evaluation of ex vivo drug sensitivity methods for identifying potentially useful and often novel therapeutic drugs for patients with myeloid neoplasms refractory to standard therapies.
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