两种治疗慢性阻塞性肺疾病的有效药物噻托溴铵和罗氟司特的分析

Yuanzi Xu
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引用次数: 0

摘要

慢性阻塞性肺疾病(COPD)以持续气道阻塞为特征,主要由支气管收缩和气道炎症引起。两种推荐药物噻托溴铵(TIO)和罗氟司特(roflumilast)分别发挥其支气管扩张和抗炎的药理作用。本文旨在全面阐述TIO和罗氟司特两种治疗COPD的药物,并对其药效学、药理学和药代动力学特性进行综述。每日一次噻托溴铵和罗氟司特均可改善患者肺功能,提示其治疗COPD的良好疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Analysis of Tiotropium bromide and Roflumilast: Two Potent Medications for Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by consistent airway obstruction, which is mainly caused by bronchoconstriction and airway inflammation. Two recommended medications, tiotropium bromide (TIO) and roflumilast, exert their pharmacological effects of bronchodilation and anti-inflammation respectively. This review's purpose is to elucidate two drug therapies, TIO and roflumilast for COPD comprehensively, therefore their pharmacodynamic, pharmacology and pharmacokinetic properties are reviewed. Both once-daily administration of tiotropium and roflumilast demonstrate improvement of patients’ lung function, suggesting their good potency to treat COPD.
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