371. 拉考恩奶羊瘤胃细菌与乳体细胞评分之间遗传联系的证据

Proceeding of 12th World Congress on Genetics Applied to Livestock Production (WCGALP) Pub Date : 2022-12-31 DOI:10.3920/978-90-8686-940-4_371

G. Martinez Boggio, A. Meynadier, R. Rupp, C. Allain, A. Buitenhuis, C. Marie-Etancelin

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引用次数: 0

摘要

乳腺炎是乳羊的一种高发传染病。即使通过乳体细胞评分(SCS)进行选择可以增加乳腺炎的抵抗力，我们想知道瘤胃细菌是否会影响乳房的炎症反应。目的是估计瘤胃细菌与平均泌乳SCS (LSCS)之间的遗传相关性，并确定性状之间的潜在机制。采用元条形码技术(16S rRNA基因)对795只拉卡乌恩母羊进行了瘤胃细菌鉴定和年度SCS记录。采用双性状基因组模型进行参数估计和GWAS。结果显示，LSCS与9个细菌操作分类单位(otu)在染色体3、17和20上存在显著的遗传相关性和共定位qtl。我们使用LSCS发现乳腺炎的抗性/易感性与瘤胃细菌丰度之间存在遗传关联。这些初步结果为更好地理解绵羊乳腺内炎症的生物学基础和因果关系铺平了道路。

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371. Evidence of genetic links between rumen bacteria and milk somatic cell score in Lacaune dairy sheep

Mastitis is a high prevalence infectious disease in dairy sheep. Even if selection by milk somatic cell score (SCS) has been implemented to increase mastitis resistance, we wonder if rumen bacteria could influence udder inflammatory response. The objectives are to estimate genetic correlations between rumen bacteria and average SCS over lactation (LSCS), and to identify underlying mechanism between traits. 795 Lacaune ewes were studied using metabarcoding (16S rRNA gene) for rumen bacteria characterization and annual SCS records. Two-trait genomic models were used for the parameter estimation and GWAS. Results showed significant genetic correlations, and colocalized QTLs for LSCS and nine bacterial operational taxonomic units (OTUs) on chromosomes 3, 17, and 20. We found a genetic association between resistance/susceptibility to mastitis, using LSCS, and the ruminal bacteria abundance. These preliminary results pave the way for better understanding the biological basis and causalities of an intra-mammary inflammations in sheep.

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Proceeding of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)

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