糖马德和罗库溴铵给药大鼠肾毒性的测定

Ö. Uludağ, Z. Doğan, E. Annaç
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引用次数: 0

摘要

背景:目前,神经肌肉阻滞剂罗库溴铵和拮抗糖马德在麻醉实践中被广泛应用。罗库溴铵和糖胺酮复合物通过肾脏排出。本研究的目的是探讨糖玛德和罗库溴铵加糖玛德对肾组织的肾毒性作用的组织病理学评价和抗氧化状态的影响。材料与方法:选取Sprague-Dawley型大鼠32只。将实验动物随机分为4组,每组8只,每组数量相等;Sham组1,Control组2,Sugammadex组3,Rocuronium + Sugammadex组4。练习后切除肾脏。研究了肾组织病理评价和抗氧化状态(测量丙二醛和谷胱甘肽水平)。结果:与其他各组相比,第4组GSH水平明显降低。与其他各组相比,第4组的MDA差异有统计学意义。4组组织病理学观察,血管充血增加,小管及小管上皮扩张变性。此外,在肾小球毛细血管和髓质区静脉中观察到扩张。结论:根据我们的研究结果,在研究中使用的剂量范围内,罗库溴铵加糖马德可引起肾脏的组织病理学变性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Determination of nephrotoxic effects due to Sugammadex and Rocuronium administration in rats
Background: Nowadays, neuromuscular blocker rocuronium and antagonizing sugammadex are being used in anesthesia practice. Rocuronium and sugammadex complexes are eliminated via the kidneys. The aim of this study was to investigate the effects of sugammadex and rocuronium plus sugammadex on histopathological evaluation and antioxidant status of kidney tissue for nephrotoxic effect. Material and method: The study included 32 Sprague-Dawley type rats. The experimental animals were randomized into four groups with equal numbers each containing 8 rats as follows; Sham Group 1, Control Group 2, Sugammadex Group 3, Rocuronium plus sugammadex Group 4. Kidneys were excised after practise. Kidney tissue histopathological evaluation and antioxidant status (measurements of MDA and GSH levels) were investigated. Results: In group 4 led to a insignificant decrease in GSH levels compared to other groups. MDA for Group 4 showed a statistically significant difference compared to all other groups. Histopathological evaluation in group 4, an increase in vascular congestion was detected and degeneration was observed in dilated tubules and tubule epithelium. In addition, dilatation was observed in the glomerular capillaries and the veins in the medulla region. Conclusion: According to our findings, Rocuronium plus sugammadex in the dose ranges used in the studies, caused histopathological degeneration in the kidneys.
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