Methodologically Study for Detection of Thermal Induced Pain via Skin Impedance

In this paper is presented an experimental study with a test commonly used in research to detect thermal induced pain level: Cold pressure test (Ice-water immersion testing). By reviewing the fundamental knowledge about defining, characterization and nociceptor pathways of pain, a mathematical approach using fractional calculus have been made in order to develop the objective tool for pain assessment via skin impedance – ANSPEC-PRO. The preliminary results validate skin impedance as a tool to identify pain and no pain states after thermal nociceptor stimulation in awake volunteers in a laboratory environment.