血清骨、肝碱性磷酸酶糖链异质性。

Enzyme Pub Date : 1991-01-01 DOI:10.1159/000468866

T Kuwana, O Sugita, M Yakata

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引用次数: 16

摘要

骨和肝碱性磷酸酶(EC 3.1.3.1)分离;通过系列凝集素亲和层析法测定血清中ALP的含量，发现血清中骨和肝脏ALP的糖链结构与先前报道的相应组织存在差异，高甘露糖或混合型糖链含量较低，双天线络合型糖链含量较高。此外，发现后者的骨和肝alp不同，骨部分显示出更多的病灶残留物。

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Sugar chain heterogeneity of bone and liver alkaline phosphatase in serum.

Fractionation of bone and liver alkaline phosphatase (EC 3.1.3.1; ALP) in serum by serial lectin affinity chromatography has demonstrated differences in the sugar chain structure of bone and liver ALP in serum from that previously reported in the corresponding tissues, with a lower content of high mannose or hybrid-type sugar chains and a higher content of biantennary complex-type chains. Furthermore, the bone and liver ALPs were found to differ in the latter with the bone fraction showing a greater content of fucose residues.

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Enzyme

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