[基于急性药物试验数据的亚硝基山梨酯、柯利法和奥比丹对慢性肝炎和肝硬化患者血流动力学的影响]。

Farmakologiia i toksikologiia Pub Date : 1991-09-01
L P Vorob'ev, I V Maev
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引用次数: 0

摘要

在复杂的临床和仪器调查中获得的数据,在门静脉和肺动脉高压综合征患者的血液动力学的背景下,急性药物试验与亚硝基山药,哥尔法和奥比丹,提出。应用现代超声和血流造影技术,评价慢性肝炎肝硬化患者门静脉高压和肺动脉高压的程度及其相互关系,探讨其早期诊断标准。亚硝基山梨碱对肾血流有积极作用,可改善肝硬化患者肺血流动力学,但对肝血流无影响。奥比旦诱导门脉高压和肺动脉高压显著降低,使总血流动力学正常化,从而产生最大的积极作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[The effect of nitrosorbide, korinfar and obzidan on the hemodynamics of patients with chronic hepatitis and liver cirrhosis based on the data acute drug trials].

The data obtained during the complex clinical and instrumental investigation of the hemodynamics in patients with the syndrome of portal and pulmonary hypertension against the background of acute drug tests with nitrosorbide, corinfar and obsidan, are presented. By using modern ultrasound and rheographic techniques, the degree and the relationship of portal and pulmonary hypertensions in patients with chronic hepatitis and cirrhosis of the liver are evaluated, the criteria of their early diagnosis are characterized. There was shown a positive action on the renal blood flow of nitrosorbide, an improvement of the pulmonary hemodynamics in patients with diseases of the liver against the background of corinfar exerting no influence on the hepatic blood flow. Obsidan induced a significant decrease of both portal and pulmonary hypertensions, normalization of the total hemodynamics thereby producing the greatest positive effect.

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