{"title":"正常情况下心肌收缩蛋白系统和毒素过敏性心肌炎的能量转导。","authors":"N V Karsanov, G V Sukoyan, D R Tatulashvili","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Energy transduction in purified myocardial myofibrils from normal rabbits and those having toxi-allergic myocarditis (TAM) was compared. In TAM a sharp decrease in the rate and value of ATP hydrolysis enthalpy released during free contraction of myofibrils takes place, and is accompanied by a rise in the amount of energy dissipated as heat. It is concluded that, at the early stages of shrinkage force generation during myofibril contraction in TAM, a breakdown of actin activation of Mg(2+)-ATPase activity for myosin occurs, the character of the bonds is changed, and the efficiency of myosin cross-bridge interaction with the protomeres of the actin thin filaments is decreased. The contractile process becomes wasteful.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Energy transduction in the myocardial contractile protein system under normal conditions and in toxi-allergic myocarditis.\",\"authors\":\"N V Karsanov, G V Sukoyan, D R Tatulashvili\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Energy transduction in purified myocardial myofibrils from normal rabbits and those having toxi-allergic myocarditis (TAM) was compared. In TAM a sharp decrease in the rate and value of ATP hydrolysis enthalpy released during free contraction of myofibrils takes place, and is accompanied by a rise in the amount of energy dissipated as heat. It is concluded that, at the early stages of shrinkage force generation during myofibril contraction in TAM, a breakdown of actin activation of Mg(2+)-ATPase activity for myosin occurs, the character of the bonds is changed, and the efficiency of myosin cross-bridge interaction with the protomeres of the actin thin filaments is decreased. The contractile process becomes wasteful.</p>\",\"PeriodicalId\":77499,\"journal\":{\"name\":\"Biomedical science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Energy transduction in the myocardial contractile protein system under normal conditions and in toxi-allergic myocarditis.
Energy transduction in purified myocardial myofibrils from normal rabbits and those having toxi-allergic myocarditis (TAM) was compared. In TAM a sharp decrease in the rate and value of ATP hydrolysis enthalpy released during free contraction of myofibrils takes place, and is accompanied by a rise in the amount of energy dissipated as heat. It is concluded that, at the early stages of shrinkage force generation during myofibril contraction in TAM, a breakdown of actin activation of Mg(2+)-ATPase activity for myosin occurs, the character of the bonds is changed, and the efficiency of myosin cross-bridge interaction with the protomeres of the actin thin filaments is decreased. The contractile process becomes wasteful.