{"title":"一种谷胱甘肽s -转移酶制剂的抗毒性。","authors":"E V Kalinina, V N Nechaev, A N Saprin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.</p>","PeriodicalId":77499,"journal":{"name":"Biomedical science","volume":"2 4","pages":"415-6"},"PeriodicalIF":0.0000,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antitoxic properties of a preparation of glutathione S-transferase.\",\"authors\":\"E V Kalinina, V N Nechaev, A N Saprin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.</p>\",\"PeriodicalId\":77499,\"journal\":{\"name\":\"Biomedical science\",\"volume\":\"2 4\",\"pages\":\"415-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biomedical science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedical science","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Antitoxic properties of a preparation of glutathione S-transferase.
Pretreatment of rats with a preparation of the cationic form of rat liver cytosolic glutathione S-transferase 1-3 h before injection of a dose of N-nitroso-N-diethylamine equivalent to the LD50 of the drug completely protects the animals against the toxic effects of the drug. The mechanism of the protective action of glutathione S-transferase is discussed.
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